Evidence map›Paper›PMID 30393656›Full record

ArticleNano-micro letters2018

Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk-Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery.

Guilan Li, Yidan Chen, Lingyu Zhang, Manjie Zhang, Shengnan Li, Lu Li, Tingting Wang, Chungang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano-micro letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guilan LiFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Yidan ChenFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Lingyu ZhangFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Manjie ZhangFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Shengnan LiFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Lu LiFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
Tingting WangSchool of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, People's Republic of China. wangtt@cust.edu.cn.
Chungang WangFaculty of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China. wangcg925@nenu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk-shell nanoparticles (NPs) composed with a PAA/CaP shell and an AuNR yolk is reported. The as-obtained AuNR@PAA/CaP yolk-shell NPs possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the CaP shell at low pH values. When the DOX-loaded AuNR@PAA/CaP yolk-shell NPs were exposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the AuNRs. Furthermore, AuNR@PAA/CaP yolk-shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.

Indexed as

Calcium phosphateDrug deliveryDual-mode imagingPhotothermal therapyYolk–shell structure

Identifiers

PMID30393656
PMCPMC6199055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.