ArticleCurrent behavioral neuroscience reports2018
Modulation of Brain Function and Behavior by Focused Ultrasound.
Article in Current behavioral neuroscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Towards neuromorphic neurotechnologies: integrating brain-inspired computing with brain-computer interfaces.npj biomedical innovations · 2026Review
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Article
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- ENHANCING TRANSCRANIAL FOCUSED ULTRASOUND TREATMENT PLANNING WITH SYNTHETIC CT FROM ULTRA-SHORT ECHO TIME (UTE) MRI: A MULTI-TASK DEEP LEARNING APPROACH.Proceedings. IEEE International Symposium on Biomedical Imaging · 2024Article
- Review
- Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound.Scientific reports · 2022Article
- Ultrasound-Mediated Bioeffects in Senescent Mice and Alzheimer's Mouse Models.Brain sciences · 2022Review
- A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Therapeutic Ultrasound as a Treatment Modality for Physiological and Pathological Ageing Including Alzheimer's Disease.Pharmaceutics · 2021Review
- Ultrasound activates mechanosensitive TRAAK KProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Investigation of the Therapeutic Effect of Doxorubicin Combined With Focused Shockwave on Glioblastoma.Frontiers in oncology · 2021Article
- Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers.Nature communications · 2020Article
- Neuromodulation Management of Chronic Neuropathic Pain in The Central Nervous system.Advanced functional materials · 2020Article
- New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions.Trends in biotechnology · 2020Review
- Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.Brain : a journal of neurology · 2020Review
- Cas9 Ribonucleoprotein Complex Delivery: Methods and Applications for Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Review
- Fast qualitative two-dimensional mapping of ultrasound fields with acoustic cavitation-enhanced ultrasound imaging.The Journal of the Acoustical Society of America · 2019Article
- Article
- Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility.Theranostics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe past decade has seen rapid growth in the application of focused ultrasound (FUS) as a tool for basic neuroscience research and potential treatment of brain disorders. Here, we review recent developments in our understanding of how FUS can alter brain activity, perception and behavior when applied to the central nervous system, either alone or in combination with circulating agents. RECENT
findingsFocused ultrasound in the central nervous system can directly excite or inhibit neuronal activity, as well as affect perception and behavior. Combining FUS with intravenous microbubbles to open the blood-brain barrier also affects neural activity and behavior, and the effects may be more sustained than FUS alone. Opening the BBB also allows delivery of drugs that do not cross the intact BBB including viral vectors for gene delivery. SUMMARY: While further research is needed to elucidate the biophysical mechanisms, focused ultrasound, alone or in combination with other factors, is rapidly maturing as an effective technology for altering brain activity. Future challenges include refining control over targeting specificity, the volume of affected tissue, cell-type specificity (excitatory or inhibitory), and the duration of neural and behavioral effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.