Evidence map›Paper›PMID 30393570›Full record

ArticleCell death discovery2018

PEGylated liposome-encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial-mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy.

Chun-Yuan Chang, Chao-Cheng Chen, Liang-Ting Lin, Chih-Hsien Chang, Liang-Cheng Chen, Hsin-Ell Wang, Te-Wei Lee, Yi-Jang Lee

Open access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
    Review
  2. LiposomalCancer science · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Brachytherapy Approach UsingPharmaceutics · 2021
    Article
  8. Review
  9. Review
  10. Translating Research for the Radiotheranostics of NanotargetedInternational journal of molecular sciences · 2021
    Review
  11. Bi-Functional Radiotheranostics ofInternational journal of molecular sciences · 2021
    Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chun-Yuan Chang1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Chao-Cheng Chen1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Liang-Ting Lin2Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Chih-Hsien Chang3Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
Liang-Cheng Chen3Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
Hsin-Ell Wang1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Te-Wei Lee3Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
Yi-Jang Lee1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWInstitute of Nuclear Energy Research · TWHong Kong Polytechnic University · HKNational Yang Ming University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human head and neck squamous cell carcinoma (HNSCC) is usually treated with chemoradiotherapy, but the therapeutic efficacy could be hampered by intrinsic radioresistance and early relapse. Repeated administrations of rhenium-188 (

Identifiers

PMID30393570
PMCPMC6208374
OpenAlexW2899428064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.