ArticleMolecular and cellular biology1987
Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.
Article in Molecular and cellular biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.Cellular signalling · 2014Article
- Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.World journal of gastroenterology · 2005Article
- Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells.Molecular and cellular biochemistry · 2000Review
- The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells.The Journal of clinical investigation · 1995Article
- Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Cyclic AMP inhibits c-Ha-ras protooncogene expression and DNA synthesis in rat aortic smooth muscle cells.Experientia · 1993Article
- Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Transferrin receptor expression and the regulation of placental iron uptake.Molecular and cellular biochemistry · 1991Article
- Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.Molecular and cellular biology · 1989Article
- Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- c-myc protein in normal tissue. Effects of fixation on its apparent subcellular distribution.The American journal of pathology · 1988Article
- Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Different growth responses to agents which elevate cAMP in human melanoma cell lines of high and low experimental metastatic capacity.Clinical & experimental metastasisArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of HL-60 cells with dibutyryl cyclic AMP induced rapid transcriptional inactivation of c-myc and the transferrin receptor. Transcriptional inactivation was followed by loss of c-myc and transferrin receptor mRNA and protein. Treated cells completed one round of proliferation, followed by growth arrest, G1 synchronization, and monocytic differentiation. These data suggest that cyclic AMP-mediated control of growth and differentiation may be achieved, at least in part, by transcriptional regulation of certain growth-associated proto-oncogenes and growth factor receptor genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.