ArticleChemical science2018
Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Programmed Fabrication of Vesicle-Based Prototissue Fibers with Modular Functionalities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Engineering Tissue-Scale Properties with Synthetic Cells: Forging One from Many.ACS synthetic biology · 2023Review
- A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death.Journal of translational medicine · 2022Article
- Multivalent glycocyclopeptides: conjugation methods and biological applications.Chemical Society reviews · 2022Review
- The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.Communications biology · 2022Article
- Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans.International journal of molecular sciences · 2022Article
- Extending Janus lectins architecture: Characterization and application to protocells.Computational and structural biotechnology journal · 2022Article
- The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake.Toxins · 2021Article
- Segregated Protein-Cucurbit[7]uril Crystalline Architectures via Modulatory Peptide Tectons.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Facile Fabrication of Protein-Macrocycle Frameworks.Journal of the American Chemical Society · 2021Article
- Glycan-decorated protocells: novel features for rebuilding cellular processes.Interface focus · 2019Review
- Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx.Interface focus · 2019Review
- 'Clickable lectins': bioorthogonal reactive handles facilitate the directed conjugation of lectins in a modular fashion.Interface focus · 2019Article
- Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB FromFrontiers in chemistry · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We engineered the first chimeric, bispecific lectin, with two rationally oriented and distinct recognition surfaces. This lectin, coined Janus lectin in allusion to the two-faced roman god, is able to bind independently to both fucosylated and sialylated glycoconjugates. The multivalent presentation of binding sites on each face of the Janus lectin is very efficient, resulting in avidities in the low nanomolar range for both fucosylated and sialylated surfaces. Moreover, novel heterovalent, bifunctional glycoclusters were synthetized that match the topology of the Janus lectin. Based on these tools, we constructed organized and controlled supramolecular architectures by assembling Janus lectin and glycocompound layer-by-layer. Furthermore, the Janus lectin was employed as biomolecular linker to organize protocells made from giant unilamellar vesicles of different nature, to more complex prototissues. In summary, tailor-made Janus lectins open wide possibilities for creating biomimetic matrices or artificial tissues.
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Registered trials
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