ArticleArchives of medical science : AMS2018
Comparative effects of methylprednisolone and tetracosactide (ACTH
Article in Archives of medical science : AMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effectiveness of Pharmacotherapy in Reducing the Inflammation Process of Spinal Cord Injuries: A Systematic Review of Animal Studies.TheScientificWorldJournal · 2024Pooled it
- Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study.Archives of medical science : AMS · 2025Article
- Effects of ADSC-Derived Exosome LRRC75A-AS1 on Anti-inflammatory Function After SCI.Applied biochemistry and biotechnology · 2024Article
- Cinnamaldehyde has ameliorative effects on rabbit spinal cord ischemia and reperfusion injury.World neurosurgery: X · 2024Article
- N-Acetylcysteine Treats Spinal Cord Injury by Inhibiting Astrocyte Proliferation.Analytical cellular pathology (Amsterdam) · 2024Article
- Activation of CREB-binding protein ameliorates spinal cord injury in tabersonine treatment by suppressing NLRP3/Notch signaling.Archives of medical science : AMS · 2023Article
- Does Anzer Propolis Have a Protective Effect on Rabbit Spinal Cord Ischemia/Reperfusion Injury?Brazilian journal of cardiovascular surgery · 2022Article
- The Repression of the HMGB1-TLR4-NF-κB Signaling Pathway by Safflower Yellow May Improve Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Phosphoglycerate Mutase 1 Prevents Neuronal Death from Ischemic Damage by Reducing Neuroinflammation in the Rabbit Spinal Cord.International journal of molecular sciences · 2020Article
- The Inhibition of Inflammatory Signaling Pathway by Secretory Leukocyte Protease Inhibitor can Improve Spinal Cord Injury.Cellular and molecular neurobiology · 2020Review
- Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model.Archives of medical science : AMS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTetracosactide is an engineered peptide that applies the same biological impacts as the endogenous adrenocorticotropic hormone. Previous studies indicated that tetracosactide has anti-inflammatory, antioxidant and neurotrophic activity. In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury. MATERIAL AND
methodsRabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide). In the control group, just a laparotomy was performed. In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein. Neurological assessment was conducted with the Tarlov scoring system. Levels of myeloperoxidase, malondialdehyde and catalase were analyzed, similar to the activities of xanthine oxidase and caspase-3. Histopathological and ultrastructural assessments were additionally performed.
resultsAfter ischemia-reperfusion injury, increments were found in the tissue myeloperoxidase levels (
conclusionsThe findings showed for the first time that tetracosactide shows significant neuroprotective activity against ischemia-reperfusion injury of the spinal cord.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.