ArticleMolecular and cellular biology1987
Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.
Article in Molecular and cellular biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 113 citations in OpenAlex.
- Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer.Molecular cancer · 2007Article
- SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta).Nucleic acids research · 2004Article
- Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator.Molecular and cellular biology · 1999Article
- Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.The EMBO journal · 1997Article
- B-cell-specific demethylation of BTK, the defective gene in X-linked agammaglobulinemia.Immunogenetics · 1995Article
- A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.Journal of virology · 1994Article
- Negative regulation of transcription in eukaryotes.The Biochemical journal · 1993Review
- Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.The EMBO journal · 1993Article
- Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer.Molecular and cellular biology · 1993Article
- Analysis of the rabbit cardiac/slow twitch muscle sarcoplasmic reticulum calcium ATPase (SERCA2) gene promoter.Nucleic acids research · 1993Article
- Distinct negative regulation of the human embryonic globin genes zeta and epsilon.Gene expression · 1993Article
- Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers.Molecular and cellular biology · 1992Article
- The transcriptional tissue specificity of the human pro alpha 1 (I) collagen gene is determined by a negative cis-regulatory element in the promoter.The Biochemical journal · 1992Article
- Negative regulation of catalase gene expression in hepatoma cells.Molecular and cellular biology · 1992Article
- Activation of immunoglobulin control elements in transgenic mice.Immunogenetics · 1992Article
- The SV40 early transcriptional regulatory element is unable to direct gene expression in pituitary GH-3 cells.Gene expression · 1992Article
- Multiple positive and negative elements regulate human brain creatine kinase gene expression.Nucleic acids research · 1991Article
- Identification of a matrix-associated region 5' of an immunoglobulin heavy chain variable region gene.Molecular and cellular biology · 1991Article
- Different mechanisms regulate muscle-specific AChR gamma- and epsilon-subunit gene expression.The EMBO journal · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.