Evidence map›Paper›PMID 30393485›Full record

ArticleArchives of medical science : AMS2018

The function and clinical relevance of lncRNA UBE2CP3-001 in human gliomas.

Zhengxiang Luo, Junchen Pan, Yi Ding, Yan-Song Zhang, Yanjun Zeng

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhengxiang LuoDepartment of Neurosurgery, Nanjing Brian Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Junchen PanDepartment of Neurosurgery, Nanjing Benq Hospital, Nanjing, Jiangsu, China.
Yi DingDepartment of Neurosurgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yan-Song ZhangDepartment of Neurosurgery, Nanjing Brian Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Yanjun ZengBiomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China.
Nanjing Medical University · CNBeijing University of Technology · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGliomas are the most frequent primary tumors in the human brain. Recent studies have identified a class of long noncoding RNAs, named lncRNAs, which were reported to participate in regulating the development of various diseases, including gliomas. In our previous studies, we found that lncRNA UBE2CP3-001 was overexpressed in gliomas but not in normal tissue. However, the molecular functions of UBE2CP3-001 in glioma are largely unknown. MATERIAL AND

methodsThe presence of UBE2CP3-001 in U87 cells, glioma tissues and normal brain tissues was detected by real-time RT-PCR. The ability of U87 cells to migrate was analyzed using a cellular wound healing assay after downregulation of UBE2CP3-001. The survival rate of U87 cells after UBE2CP3-001 knockdown was also analyzed using the CCK8 assay.

resultsOur data showed that UBE2CP3-001 was overexpressed in most glioma tissues (

conclusionsThese data suggest an important role of UBE2CP3-001 in glioma and indicate its potential application in anti-glioma therapy.

Indexed as

apoptosisgliomalncRNA UBE2CP3-001proliferationTRAF3IP2

Identifiers

PMID30393485
PMCPMC6209712
OpenAlexW2898598696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.