Evidence map›Paper›PMID 30393475›Full record

ReviewArchives of medical science : AMS2018

Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.

Cui Zhai, Shaojun Li, Wei Feng, Wenhua Shi, Jian Wang, Qingting Wang, Limin Chai, Qianqian Zhang, Xin Yan, Manxiang Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of medical science : AMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. The role of heterodimer IL-17-A/F in atopic dermatitis.Postepy dermatologii i alergologii · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Influence of theJournal of personalized medicine · 2021
    Article
  12. Article
  13. The Role of Immunogenetics in COVID-19.International journal of molecular sciences · 2021
    Review
  14. An update on the diagnostic biomarkers for asthma.Journal of family medicine and primary care · 2021
    Review
  15. Impact of Single-Nucleotide Polymorphisms ofJournal of personalized medicine · 2020
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Cui ZhaiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Shaojun LiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Wei FengDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Wenhua ShiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Jian WangDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Qingting WangDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Limin ChaiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Qianqian ZhangDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Xin YanDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Manxiang LiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInterleukin-17A (IL-17A), a pro-inflammatory cytokine, plays an important role in the pathogenesis of asthma. A number of studies have investigated the relationship between IL-17A rs2275913 polymorphism and risk of asthma. However, the results obtained are inconclusive. The aim of this meta-analysis is to clarify the relationship between IL-17A rs2275913 polymorphism and asthma risk. MATERIAL AND

methodsSearches were conducted in PubMed, Web of Science, Elsevier, Google Scholar, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases, and data were extracted from eligible studies by two independent reviewers. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed.

resultsTen studies with a total of 5016 subjects were included. Overall, the results indicated a significant association between the IL-17A rs2275913 polymorphism and the risk of asthma (G vs. A: OR = 0.866, 95% CI: 0.789-0.951,

conclusionsThe results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.

Indexed as

asthmainterleukin-17ameta-analysispolymorphismrisk

Identifiers

PMID30393475
PMCPMC6209699
OpenAlexW2791921542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.