ReviewInternational journal of oral science2018
The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein.
Review in International journal of oral science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Single-Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis.Cell proliferation · 2026Article
- Reduced Dietary Protein Induces Changes in the Dental Proteome.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Ultrastructural Aspects of Physiological Mineralization: A Comparative Study in Different Hard Tissues.Biomolecules · 2025Article
- Selective HDAC4 inhibition by SP1-PTD promotes odontoblast differentiation.Journal of applied oral science : revista FOB · 2025Article
- BioceramicHistology and histopathology · 2024Review
- Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing.Nanomedicine : nanotechnology, biology, and medicine · 2024Review
- Progress in the pathogenic mechanism, histological characteristics of hereditary dentine disorders and clinical management strategies.Frontiers in cell and developmental biology · 2024Review
- Research progress of biomimetic materials in oral medicine.Journal of biological engineering · 2023Review
- Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue.NPJ Regenerative medicine · 2023Article
- p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK.Frontiers in cell and developmental biology · 2023Article
- NBCe1 Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells via NF-International journal of stem cells · 2022Article
- Dentin Sialoprotein/Phosphophoryn (DSP/PP) as Bio-Inductive Materials for Direct Pulp Capping.Polymers · 2022Article
- Label-free quantitative proteomics reveals molecular correlates of altered biomechanical properties in molar incisor hypomineralization (MIH): an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Article
- Concentration of dentin sialoprotein at the initial stage of orthodontic treatment using self-ligating and conventional preadjusted brackets: A pilot study.Journal of orthodontic science · 2022Article
- Phenotype and molecular characterizations of a family with dentinogenesis imperfecta shields type II with a novelAnnals of translational medicine · 2021Article
- Effects ofGlobal medical genetics · 2021Review
- Preparation of Absorption-Resistant Hard Tissue Using Dental Pulp-Derived Cells and Honeycomb Tricalcium Phosphate.Materials (Basel, Switzerland) · 2021Article
- A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption.International journal of molecular sciences · 2021Review
- Dentin Phosphophoryn-Derived Peptide Promotes Odontoblast Differentiation In Vitro and Dentin Regeneration In Vivo.Materials (Basel, Switzerland) · 2021Article
- Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair.International journal of oral science · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Historically, these two proteins were considered to be independently synthesized and secreted by dental pulp cells into the developing dentin matrix. However, with the identification of the DSP coding sequence in 1994, followed 2 years later by the finding that the PP coding sequence was located immediately downstream from the DSP sequence, it became immediately clear that DSP and PP proteins were derived from a single DSP-PP (i.e., dentin sialophosphoprotein, DSPP) transcript. Since DSPP cDNA became available, tremendous progress has been made in studying DSP-PP mRNA distribution and DSP generation from the DSP-PP precursor protein at specific cleavage sites by protease tolloid-related-1 (TLR1) or bone morphogenetic protein 1 (BMP1). The functions of DSP-PP and DSP were investigated via DSP-PP knockout (KO) and DSP knockin in DSP-PP KO mice. In addition, a number of in vitro studies aimed to elucidate DSPP and DSP function in dental pulp cells.
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