ArticleMicromachines2018
In Vivo Experimental Study of Noninvasive Insulin Microinjection through Hollow Si Microneedle Array.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Sustainable Hydrogel-Forming Microneedle-Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Current Situation on Diabetes Management: New Weapons Fighting the Disease in 2025.Current drug targets · 2026Review
- Recent progress of NIR light-controlled microneedles and therapeutic applications: A review study.Journal of materials science. Materials in medicine · 2025Review
- Mathematical modelling of hollow microneedle-mediated transdermal drug delivery.Drug delivery and translational research · 2025Article
- Microneedles in biomedicine: Innovations, challenges, and future prospects.Biomaterials translational · 2025Review
- Porous silicon and silica carriers for delivery of peptide therapeutics.Drug delivery and translational research · 2024Review
- Microfluidic-based systems for the management of diabetes.Drug delivery and translational research · 2024Review
- Aspirin microcrystals deposited on high-density microneedle tips for the preparation of soluble polymer microneedles.Drug delivery and translational research · 2023Article
- Customized flexible hollow microneedles for psoriasis treatment with reduced-dose drug.Bioengineering & translational medicine · 2023Article
- Soluble Polymer Microneedles Loaded with Interferon Alpha 1b for Treatment of Hyperplastic Scar.Polymers · 2023Article
- Wearable patches for transdermal drug delivery.Acta pharmaceutica Sinica. B · 2023Review
- A Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers.Micromachines · 2022Article
- Design and development of insulin microneedles for diabetes treatment.Drug delivery and translational research · 2022Review
- Microneedle-Based Vaccine Delivery: Review of an Emerging Technology.AAPS PharmSciTech · 2022Review
- Microneedles in Drug Delivery: Progress and Challenges.Micromachines · 2021Review
- Batch Fabrication of Silicon Nanometer Tip Using Isotropic Inductively Coupled Plasma Etching.Micromachines · 2020Article
- Microneedle-Based Delivery: An Overview of Current Applications and Trends.Pharmaceutics · 2020Review
- Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis.RSC advances · 2020Review
- Microneedle Patterning of 3D Nonplanar Surfaces on Implantable Medical Devices Using Soft Lithography.Micromachines · 2019Article
- Advances in transdermal insulin delivery.Advanced drug delivery reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An experimental study of in vivo insulin delivery through microinjection by using hollow silicon microneedle array is presented. A case study was carried out on a healthy human subject in vivo to determine the influence of delivery parameters on drug transfer efficiency. As a microinjection device, a hollow microneedle array (13 × 13 mm²) having 100 microneedles (220 µm high, 130 µm-outer diameter and 50 µm-inner diameter) was designed and fabricated using classical microfabrication techniques. The efficiency of the delivery process was first characterized using methylene blue and a saline solution. Based on these results, the transfer efficiency was found to be predominantly limited by the inability of viable epidermis to absorb and allow higher drug transport toward the capillary-rich region. Two types of fast-acting insulin were used to provide evidence of efficient delivery by hollow MNA to a human subject. By performing blood analyses, infusion of more-concentrated insulin (200 IU/mL, international units (IU)) exhibited similar blood glucose level drop (5⁻7%) compared to insulin of standard concentration (100 IU/mL), however, significant increase of serum insulin (40⁻50%) with respect to the preinfusion values was determined. This was additionally confirmed by a distinctive increase of insulin to C-peptide ratio as compared to preinfusion ratio. Moreover, we noticed that this route of administration mimics a multiple dose regimen, able to get a "steady state" for insulin plasma concentration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.