Evidence map›Paper›PMID 30393295›Full record

ArticleMicromachines2018

A Wireless Implant for Gastrointestinal Motility Disorders.

Yi-Kai Lo, Po-Min Wang, Genia Dubrovsky, Ming-Dao Wu, Michael Chan, James C Y Dunn, Wentai Liu

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Robotic Setup Promises Consistent Effects of Multilocular Gastrointestinal Electrical Stimulation: First Results of a Porcine Study.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yi-Kai LoNiche Biomedical, LLC, Los Angeles, CA 90095, USA. yikai@nichebio.com.
Po-Min WangDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA. pominwang@g.ucla.edu.
Genia DubrovskyDepartment of Surgery, University of California, Los Angeles, CA 90095, USA. GDubrovsky@mednet.ucla.edu.
Ming-Dao WuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA. bodombodom@ucla.edu.
Michael ChanDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA. chanmi168@gmail.com.
James C Y DunnDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA. jdunn2@stanford.edu.
Wentai LiuDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA. wentai@ucla.edu.
University of California, Los Angeles · USStanford University · US

Funding

National Science Foundation 1647917
6 · The paper itself

Abstract

Implantable functional electrical stimulation (IFES) has demonstrated its effectiveness as an alternative treatment option for diseases incurable pharmaceutically (e.g., retinal prosthesis, cochlear implant, spinal cord implant for pain relief). However, the development of IFES for gastrointestinal (GI) tract modulation is still limited due to the poorly understood GI neural network (gut⁻brain axis) and the fundamental difference among activating/monitoring smooth muscles, skeletal muscles and neurons. This inevitably imposes different design specifications for GI implants. This paper thus addresses the design requirements for an implant to treat GI dysmotility and presents a miniaturized wireless implant capable of modulating and recording GI motility. This implant incorporates a custom-made system-on-a-chip (SoC) and a heterogeneous system-in-a-package (SiP) for device miniaturization and integration. An in vivo experiment using both rodent and porcine models is further conducted to validate the effectiveness of the implant.

Indexed as

bioelectronics medicineelectroceuticalsgastrointestinal stimulationimplantmotilityneuromodulationwireless power and data telemetry

Identifiers

PMID30393295
PMCPMC6187657
OpenAlexW2782440494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.