Evidence map›Paper›PMID 30393084›Full record

ArticleThe Journal of investigative dermatology2019

Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice.

Chandra K Singh, Charlotte A Mintie, Mary A Ndiaye, Gagan Chhabra, Panshak P Dakup, Ting Ye, Menggang Yu, Nihal Ahmad

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chandra K SinghDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Charlotte A MintieDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Mary A NdiayeDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Gagan ChhabraDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Panshak P DakupDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Ting YeDepartment of Statistics, University of Wisconsin, Madison, Wisconsin, USA.
Menggang YuDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, USA.
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA; William S. Middleton Veterans Affairs Medical Center, Madison, Wisconsin, USA. Electronic address: nahmad@wisc.edu.
University of Wisconsin–Madison · USWashington State University Spokane · USWilliam S. Middleton Memorial Veterans Hospital · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Role of Polo-Like Kinase-1 in Melanocytic TransformationR01AR059130 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2010 to 2019
$3.8M
Skin Diseases Research Center at the University of WisconsinP30AR066524 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI LONGLEY, B JACK · 2014 to 2018
$2.6M
Role of SIRT1 in melanocyte biology and melanocyte transformationR01CA176748 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2013 to 2017
$1.6M
Plk1-Numb Cooperation in MelanomagenesisI01BX001008 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2013 to 2016
–
BLR&D Research Career Scientist Award ApplicationIK6BX003780 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2017 to 2021
–
Role of SIRT3 in melanoma development and progressionI01CX001441 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2017 to 2022
–
BLRD VA I01 BX001008BLRD VA IK6 BX003780CSRD VA I01 CX001441NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA176748NIAMS NIH HHS P30 AR066524NIAMS NIH HHS R01 AR059130
6 · The paper itself

Abstract

Skin cancer is the most frequently diagnosed cancer in the United States, and solar UVR is an established causative factor for approximately 90% of these cases. Despite efforts aimed at UV protection, including use of sunscreen and clothing, annual cases of skin cancer continue to rise. Here, we report that dietary grape powder mitigates UVB-mediated skin carcinogenesis in an SKH-1 hairless mouse model. Using a UVB initiation-promotion protocol, whereby mice were exposed to 180 mJ/cm

Indexed as

Dietary SupplementsAnimalsAntioxidantsBiopsy, NeedleCarcinogenesisChemopreventionDisease Models, AnimalFemaleImmunohistochemistryMiceMice, HairlessRandom AllocationReference ValuesSkin NeoplasmsUltraviolet RaysVitisAntioxidants

Identifiers

PMID30393084
PMCPMC6533915
OpenAlexW2898226123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.