Evidence map›Paper›PMID 30393038›Full record

ArticleCurrent biology : CB2018

Multisensory Control of Orientation in Tethered Flying Drosophila.

Timothy A Currier, Katherine I Nagel

Abstract read
In one paragraph

Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Multisensory integration for active mechanosensation inbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021
    Review
  8. Article
  9. Multisensory control of navigation in the fruit fly.Current opinion in neurobiology · 2020
    Review
  10. Characterizing long-range search behavior in Diptera using complex 3D virtual environments.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Multimodal cue integration in the dung beetle compass.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy A CurrierNeuroscience Institute, New York University Medical Center, 435 E. 30(th) Street, New York, NY 10016, USA; Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
Katherine I NagelNeuroscience Institute, New York University Medical Center, 435 E. 30(th) Street, New York, NY 10016, USA; Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. Electronic address: katherine.nagel@nyumc.org.

Funding

The role of short-term synaptic plasticity in sensory processing and behaviorR01MH109690 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAGEL, KATHERINE · 2016 to 2020
$2.0M
Olfactory navigation in Drosophila as a model for multi-sensory integrationR00DC012065 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAGEL, KATHERINE · 2014 to 2016
$745k
NIDCD NIH HHS R00 DC012065NIMH NIH HHS R01 MH109690
6 · The paper itself

Abstract

A longstanding goal of systems neuroscience is to quantitatively describe how the brain integrates sensory cues over time. Here, we develop a closed-loop orienting paradigm in Drosophila to study the algorithms by which cues from two modalities are integrated during ongoing behavior. We find that flies exhibit two behaviors when presented simultaneously with an attractive visual stripe and aversive wind cue. First, flies perform a turn sequence where they initially turn away from the wind but later turn back toward the stripe, suggesting dynamic sensory processing. Second, turns toward the stripe are slowed by the presence of competing wind, suggesting summation of turning drives. We develop a model in which signals from each modality are filtered in space and time to generate turn commands and then summed to produce ongoing orienting behavior. This computational framework correctly predicts behavioral dynamics for a range of stimulus intensities and spatial arrangements.

Indexed as

AnimalsBrainCuesDrosophila melanogasterFeedback, SensoryFlight, AnimalOrientationOrientation, SpatialPhotic StimulationSensationVisual PerceptionWindbehaviorDrosophilaintegrationmechanosensationmultisensorynavigationorientationvision

Identifiers

PMID30393038
PMCPMC6503675

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.