ArticleCurrent biology : CB2018
Hippocampal Place Fields Maintain a Coherent and Flexible Map across Long Timescales.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 120 citations in OpenAlex.
- Hippocampal conditioning code dominates and disrupts the place code.bioRxiv : the preprint server for biology · 2026Article
- Neural substrate of conditioned stimulus for associative learning in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Discrete and differentiated encoding of distinct components of spatial experience occurs within the proximodistal subfields of the dorsoventral axis of the hippocampus.Frontiers in behavioral neuroscience · 2026Article
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Erasable hippocampal neural signatures predict memory discrimination.Cell reports · 2025Article
- Erasable Hippocampal Neural Signatures Predict Memory Discrimination.bioRxiv : the preprint server for biology · 2024Article
- Vector coding and place coding in hippocampus share a common directional signal.Nature communications · 2024Article
- Neuroplasticity Meets Artificial Intelligence: A Hippocampus-Inspired Approach to the Stability-Plasticity Dilemma.Brain sciences · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Article
- Accurate neuron segmentation method for one-photon calcium imaging videos combining convolutional neural networks and clustering.Communications biology · 2024Article
- Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation.Nature communications · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reward Expectation Reduces Representational Drift in the Hippocampus.bioRxiv : the preprint server for biology · 2023Article
- Estimating neuronal firing density: A quantitative analysis of firing rate map algorithms.PLoS computational biology · 2023Article
- Article
- The temporal and contextual stability of activity levels in hippocampal CA1 cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To provide a substrate for remembering where in space events have occurred, place cells must reliably encode the same positions across long timescales. However, in many cases, place cells exhibit instability by randomly reorganizing their place fields between experiences, challenging this premise. Recent evidence suggests that, in some cases, instability could also arise from coherent rotations of place fields, as well as from random reorganization. To investigate this possibility, we performed in vivo calcium imaging in dorsal hippocampal region CA1 of freely moving mice while they explored two arenas with different geometry and visual cues across 8 days. The two arenas were rotated randomly between sessions and then connected, allowing us to probe how cue rotations, the integration of new information about the environment, and the passage of time concurrently influenced the spatial coherence of place fields. We found that spatially coherent rotations of place-field maps in the same arena predominated, persisting up to 6 days later, and that they frequently rotated in a manner that did not match that of the arena rotation. Furthermore, place-field maps were flexible, as mice frequently employed a similar, coherent configuration of place fields to represent each arena despite their differing geometry and eventual connection. These results highlight the ability of the hippocampus to retain consistent relationships between cells across long timescales and suggest that, in many cases, apparent instability might result from a coherent rotation of place fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.