Evidence map›Paper›PMID 30392834›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2019

Differential Expression of Vascular Endothelial Growth Factor-A

Hao Jiang, Juan F Toscano, Michael Schiraldi, Shlee S Song, Konrad H Schlick, Oana M Dumitrascu, Raymond Liou, Patrick D Lyden, Jianwei Pan, Renya Zhan and 2 more

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Hao JiangDepartment of Neurosurgery, Gonzalez Neurovascular Laboratory, Cedars-Sinai Medical Center, Los Angeles, California; Department of Neurosurgery, The First Affiliated Hospital of Zhejiang University-School of Medicine. Hangzhou, China. Electronic address: neurosurg_jh@163.com.
Juan F ToscanoDepartment of Neurosurgery, Gonzalez Neurovascular Laboratory, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Juan.Toscano@cshs.org.
Michael SchiraldiDepartment of Neurosurgery, Gonzalez Neurovascular Laboratory, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Michael.Schiraldi@cshs.org.
Shlee S SongDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Shlee.Song@cshs.org.
Konrad H SchlickDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Konrad.Schlick@cshs.org.
Oana M DumitrascuDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Oana.Dumitrascu@cshs.org.
Raymond LiouStanford University, School of Medicine, Palo Alto, California. Electronic address: rliou@stanford.edu.
Patrick D LydenDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Patrick.Lyden@cshs.org.
Jianwei PanDepartment of Neurosurgery, The First Affiliated Hospital of Zhejiang University-School of Medicine. Hangzhou, China. Electronic address: swordman_pan@aliyun.com.
Renya ZhanDepartment of Neurosurgery, The First Affiliated Hospital of Zhejiang University-School of Medicine. Hangzhou, China. Electronic address: zyyyzry@163.com.
Jeffrey L SaverDepartment of Neurology, University of California Los Angeles, Los Angeles, California. Electronic address: JSaver@mednet.ucla.edu.
Nestor R GonzalezDepartment of Neurosurgery, Gonzalez Neurovascular Laboratory, Cedars-Sinai Medical Center, Los Angeles, California; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Nestor.Gonzalez@cshs.org.
Cedars-Sinai Medical Center · USFirst Affiliated Hospital Zhejiang University · CNPalo Alto University · USUniversity of California, Los Angeles · US

Funding

Thrombin Mediated Cytotoxicity during Cerebral IschemiaR01NS075930 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LYDEN, PATRICK D · 2011 to 2020
$3.6M
Surgical Indirect Revascularization For Symptomatic Intracranial Aterial StenosisK23NS079477 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONZALEZ, NESTOR RAUL · 2013 to 2017
$842k
NINDS NIH HHS K23 NS079477NINDS NIH HHS R01 NS075930
6 · The paper itself

Abstract

backgroundVascular endothelial growth factor-A

methodsSixty-six ICAD patients, 6 MMD patients, and 5 controls were enrolled in this prospective study. ICAD and MMD patients received intensive medical management upon enrollment. Surgery was offered to 9 ICAD patients who had recurrent ischemic events, 6 MMD patients, and 5 surgical controls without ICAD. VEGF-A

resultsA significantly higher baseline VEGF-A

conclusionsOur study shows an increased VEGF-A

Indexed as

AdultBiomarkersCase-Control StudiesFemaleHumansIntracranial ArteriosclerosisLos AngelesMaleMiddle AgedMoyamoya DiseaseProspective StudiesProtein IsoformsTime FactorsTreatment OutcomeVascular Endothelial Growth Factor ABiomarkersProtein IsoformsVascular Endothelial Growth Factor AVEGFA protein, humanVEGF-A(165)–isoforms–intracranial atherosclerosis–moyamoya disease

Identifiers

PMID30392834
PMCPMC6786492
OpenAlexW2898730830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.