Observational studyChest2019
ICU Admission Muscle and Fat Mass, Survival, and Disability at Discharge: A Prospective Cohort Study.
Observational study in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- THE EFFECT OF A SINGLE ORAL DOSE OF L-ARGININE ON QUADRICEPS STRENGTH IN SMOKERS AND NON-SMOKERS: A NON-RANDOMIZED CLINICAL TRIAL.Acta clinica Croatica · 2024Trial
- Added Value of Quadriceps Muscle Layer Thickness to modified Nutrition Risk in the Critically Ill (mNUTRIC) Score in Predicting Clinical Outcomes in Critically Ill Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Muscle ultrasound in heart failure: pathophysiological profiling and clinical stratification.Internal and emergency medicine · 2026Review
- Tibialis anterior pennation angle at ICU admission and 60-day mortality in critically ill patients: a prospective observational study.Frontiers in medicine · 2026Article
- Factors of pre-existing low muscle mass and its relationship with mortality in critically ill patients: a sex-specific analysis.Frontiers in medicine · 2026Article
- Long-term DNA methylation changes induced by age and elevated COSkeletal muscle · 2025Article
- Article
- The role of adipose tissue in critical illness-induced skeletal muscle wasting-new considerations for treatment approaches.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Different trend of muscle wasting extracted from computed tomography in patients with severe acute pancreatitis.Abdominal radiology (New York) · 2025Article
- The flux of energy in critical illness and the obesity paradox.Physiological reviews · 2025Review
- Article
- Observational
- Impact of Protein and Nutritional Support on the Muscular Status of Critically Ill Patients: A Pilot, Perspective, and Exploratory Study.Nutrients · 2025Article
- Rapamycin improves satellite cells' autophagy and muscle regeneration during hypercapnia.JCI insight · 2025Article
- Methodologies and clinical applications of lower limb muscle ultrasound in critically ill patients: a systematic review and meta-analysis.Annals of intensive care · 2024Review
- Creatinine clearance/eGFR ratio: a simple index for muscle mass related to mortality in ICU patients.BMC nephrology · 2024Article
- Cluster analysis of thoracic muscle mass using artificial intelligence in severe pneumonia.Scientific reports · 2024Article
- Malnutrition and pectoralis muscle index in medical intensive care unit patients: A matched cohort study.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Factors Associated with Nutritional Risk Assessment in Critically Ill Patients Using the Malnutrition Universal Screening Tool (MUST).Journal of clinical medicine · 2024Article
- Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure.JHEP reports : innovation in hepatology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundSkeletal muscle dysfunction occurring as a result of ICU admission associates with higher mortality. Although preadmission higher BMI correlates with better outcomes, the impact of baseline muscle and fat mass has not been defined. We therefore investigated the association of skeletal muscle and fat mass at ICU admission with survival and disability at hospital discharge.
methodsThis single-center, prospective, observational cohort study included medical ICU (MICU) patients from an academic institution in the Unites States. A total of 401 patients were evaluated with pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) determinations conducted by CT scanning at the time of ICU admission, which were later correlated with clinical outcomes accounting for potential confounders.
resultsLarger admission PMA was associated with better outcomes, including higher 6-month survival (OR, 1.03; 95% CI, 1.01-1.04; P < .001), lower hospital mortality (OR, 0.96; 95% CI, 0.93-0.98; P < .001), and more ICU-free days (slope, 0.044 ± 0.019; P = .021). SAT was not significantly associated with any of the measured outcomes. In multivariable analyses, PMA association persisted with 6 months and hospital survival and ICU-free days, whereas SAT remained unassociated with survival or other outcomes. PMA was not associated with regaining of independence at the time of hospital discharge (OR, 0.99; 95% CI, 0.98-1.01; P = .56).
conclusionsIn this study cohort, ICU admission PMA was associated with survival during and following critical illness; it was unable to predict regaining an independent lifestyle following discharge. ICU admission SAT mass was not associated with survival or other measured outcomes.
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