ArticleEnvironmental science and pollution research international2019
Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 72 citations in OpenAlex.
- Evaluation of bromadiolone combined with ciprofloxacin, vitamin D, aspirin, and cinnamon as an apoptosis-mediated rodenticide strategy.Scientific reports · 2025Article
- Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis.Redox report : communications in free radical research · 2025Article
- Article
- Allicin and Omega-3 fatty acids attenuates acetaminophen mediated renal toxicity and modulates oxidative stress, and cell apoptosis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Combined effects of water salinity and ammonia exposure on the antioxidative status, serum biochemistry, and immunity of Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2023Article
- Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Aqueous Extract of Cinnamon (Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Hepatoprotective Effects of Radish (Nutrients · 2022Article
- Thymoquinone Alleviates Cadmium Induced Stress in GerminatedLife (Basel, Switzerland) · 2022Article
- Tigecycline and Gentamicin-Combined Treatment Enhances Renal Damage: Oxidative Stress, Inflammatory Reaction, and Apoptosis Interplay.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Article
- Biofunctional significance of multi-herbal combination against paracetamol-induced hepatotoxicity in Wistar rats.Environmental science and pollution research international · 2021Article
- Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice.Environmental science and pollution research international · 2021Article
- A randomized and comparative study to assess safety and efficacy of supplemental treatment of a herbal formulation -Contemporary clinical trials communications · 2021Article
- Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats.Experimental animals · 2021Article
- Comparative immuno-modulatory effects of basil and sesame seed oils against diazinon-induced toxicity in rats; a focus on TNF-α immunolocalization.Environmental science and pollution research international · 2021Article
- Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats.Veterinary sciences · 2021Article
- Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen, APAP, is a common over-the-counter drug with antipyretic-analgesic action. When APAP is used in large doses, it causes hepatotoxicity and nephrotoxicity but safe at therapeutic doses. Cinnamon (Cinnamomum zeylanicum) is extensively used in folk medicine due to its high content of natural antioxidants. The current investigation was planned to study the possible ameliorative effect of cinnamon toward induced APAP-apoptosis and cellular damage in renal cells. Four groups (nine rats each) were used; negative control group administrated distilled water for 15 days; positive control APAP group administrated a single dose of APAP (1 g/kg) orally on the last day; APAP+Cin L (200 mg/kg) and APAP+Cin H (400 mg/kg) aqueous extract of cinnamon orally once a day for 15 days. An hour after the last dose of cinnamon, all rats in the third and fourth group were administrated a single dose of APAP (1 g/kg) orally. GC/MS analysis was performed to identify the plant used in the study. APAP markedly increased serum levels of creatinine, BUN, and glucose and decreased levels of albumin and total protein. In addition, APAP could also exert severe alteration in the kidney histopathology along with upregulation of caspase-3 and PCNA. However, pre-treatment with cinnamon ameliorated the APAP-induced cellular alterations and apoptosis, possibly through its high content of antioxidants.
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