Evidence map›Paper›PMID 30392168›Full record

ArticleJournal of natural medicines2019

Screening for natural medicines effective for the treatment of osteoporosis.

Ryuichiro Suzuki, Satoshi Fukami, Mineko Tomomura, Akito Tomomura, Yoshiaki Shirataki

Open access · greenAbstract readLetter
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Isolation of Pro-Osteogenic Compounds fromInternational journal of molecular sciences · 2023
    Article
  2. Article
  3. The Role of Macrophage in the Pathogenesis of Osteoporosis.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryuichiro SuzukiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan. ryu_suzu@josai.ac.jp.ORCID http://orcid.org/0000-0002-3492-1671
Satoshi FukamiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan.
Mineko TomomuraIntegrated Education Center, Meikai University, 1 Miekai, Urayasu, Chiba, Japan.
Akito TomomuraDivision of Biochemistry, Department of Oral Biology and Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, Japan.
Yoshiaki ShiratakiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan.
Josai University · JPMeikai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone-forming osteoblasts are differentiated from mesenchymal stem cells and dysregulation of this differentiation can lead to osteoporosis. Meanwhile, bone-resorbing osteoclasts are both differentiated and multinucleated from hematopoietic precursor cells of monocyte and/or macrophage lineage. Bone resorption inhibitors such as bisphosphonates and estrogen are used to treat osteoporosis. However, the adverse effects of the long-term use of these medicines are of concern, and so the development of new therapies to ameliorate osteoporosis is desirable. Therefore, in the present study, we screened 22 plant extracts and found that nine methanolic extracts of plants promote the differentiation of MC3T3-E1 cells to osteoblasts. These nine extracts were then evaluated for their inhibitory activity on osteoclast differentiation in RAW264.7 mouse macrophage cells. Of the nine extracts, Daucus carota, Vitis spp., Sasa veitchii, Euptelea polyandra, and Sesamum indicum exhibited pro-osteoblastic and anti-osteoclastic activity with low cytotoxicity, suggesting their potential effectiveness against osteoporosis.

Indexed as

AnimalsHerbal MedicineMiceOsteoblastsOsteoclastsOsteoporosisPlant ExtractsRAW 264.7 CellsPlant ExtractsMC3T3-E1 cellsOsteoblast differentiationOsteoclast differentiationOsteoporosisPlant extractsRAW264.7 mouse macrophage cells

Identifiers

PMID30392168
OpenAlexW2899249554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.