ArticlePediatric surgery international2019
Clinical characteristics and prognosis of adrenocortical tumors in children.
Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Spotting childhood abdominal tumours: a systematic review and meta-analysis of the clinical presentation.Archives of disease in childhood · 2026Pooled it
- Mitotane dosage, plasma levels, and anthropometric measurements in pediatric adrenocortical carcinoma.Endocrine oncology (Bristol, England) · 2026Article
- Adrenocortical tumors in children: Sri Lankan experience from a single center, and a mini review.Journal of medical case reports · 2023Review
- Case Report: Adrenocortical carcinoma in children-symptoms, diagnosis, and treatment.Frontiers in endocrinology · 2023Review
- Retrospective Analysis of Prognostic Factors in Pediatric Patients with Adrenocortical Tumor from Unique Tertiary Center with Long-Term Follow-Up.Journal of clinical medicine · 2022Review
- Laparoscopic approach of pediatric adrenal tumors.Pediatric surgery international · 2022Article
- Review
- Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience.Frontiers in oncology · 2020Article
- Adrenocortical Neoplasms in Children: Treatment and Outcomes.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study was to review the clinical characteristics and prognosis of children with adrenocortical tumors (ACT).
methodsWe retrospectively reviewed the medical records of 28 patients with ACT at our hospital between March 2010 and March 2017.
resultsThe main clinical presentations were sexual prematurity (n = 17) and Cushing's syndrome (n = 15). All patients without metastasis underwent complete resection by laparotomy (n = 19) or laparoscopic surgery (n = 9). Pathological diagnosis confirmed adrenocortical carcinomas (ACC, n = 12) and adrenocortical adenomas (ACA, n = 16). Dehydroepiandrosterone (939.4 ± 148.2 µg/dl vs 630.9 ± 376.3 µg/dl; p = 0.031) and testosterone (235.7 ± 89.1 ng/dl vs 164.6 ± 47.5 ng/dl; p = 0.012) were significantly increased in ACC compared with ACA. The ACC tumor volumes were larger than those in ACA (107.5 ± 69 vs 25.5 ± 23.1 cm
conclusionsPatients with ACC had significantly larger tumor volumes than those with ACA. The discordantly elevated serum levels of sexual corticosteroid hormones and lactate dehydrogenase may predict the malignant nature of these tumors. The prognosis of patients with ACA was good, while those with ACC had high postoperative metastasis and mortality rates.
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