ArticleJournal of biological physics2019
Mathematical expression of membrane potential based on Ling's adsorption theory is approximately the same as the Goldman-Hodgkin-Katz equation.
Article in Journal of biological physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 33 citations in OpenAlex.
- Investigate channel rectifications and neural dynamics by an electrodiffusive Gauss-Nernst-Planck approach.PLoS computational biology · 2025Article
- Biomolecular Condensates can Induce Local Membrane Potentials.bioRxiv : the preprint server for biology · 2024Article
- Biomolecular Condensates are Characterized by Interphase Electric Potentials.Journal of the American Chemical Society · 2024Article
- Chemically diverse antimicrobial peptides induce hyperpolarization of the E. coli membrane.Communications biology · 2024Article
- COVID-19, Cation Dysmetabolism, Sialic Acid, CD147, ACE2, Viroporins, Hepcidin and Ferroptosis: A Possible Unifying Hypothesis.F1000Research · 2022Review
- What can S-shaped potential profiles tell us about the mechanism of membrane potential generation?European biophysics journal : EBJ · 2021Article
- Cells in New Light: Ion Concentration, Voltage, and Pressure Gradients across a Hydrogel Membrane.ACS omega · 2020Article
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1 author at 1 institution in 1 country.
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Abstract
The Goldman-Hodgkin-Katz equation (GHK equation), one of the most successful achievements of membrane theory in electrophysiology, can precisely predict the membrane potential. Its conceptual foundation lies in the idea that the transmembrane ion transport across the plasma membrane is responsible for the membrane potential generation. However, the potential virtually equivalent to the membrane potential is generated even across the impermeable membrane. In this work, I discus the membrane potential generation mechanism and find that the potential formula based on the long-dismissed Ling's adsorption theory, which attributes the membrane potential generation to the mobile ion adsorption rather than the transmembrane ion transport, is the same as the GHK equation. Based on this finding, I derive a conclusion that the membrane potential is generated by the ion adsorption against the existing electrophysiological concept.
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