ArticleJournal of materials science. Materials in medicine2018
Optimising collagen scaffold architecture for enhanced periodontal ligament fibroblast migration.
Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Review
- Data-driven multiscale design of composite biomaterials: Integrating experiments, imaging, and computational modeling for biomedical engineering.Materials today. Bio · 2026Review
- Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype.Advanced healthcare materials · 2026Article
- Novel Applications of Natural Biomaterials in Dentistry-Properties, Uses, and Development Perspectives.Materials (Basel, Switzerland) · 2025Review
- Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers.Bioengineering (Basel, Switzerland) · 2024Review
- One-stage cartilage repair using the autologous matrix-induced chondrogenesis combined with simultaneous use of autologous adipose tissue graft and adipose tissue mesenchymal cells technique: clinical results and magnetic resonance imaging evaluation at five-year follow-up.International orthopaedics · 2024Article
- Poly(3-hydroxybutyrate) 3D-Scaffold-Conduit for Guided Tissue Sprouting.International journal of molecular sciences · 2023Article
- Drug Delivery Systems in Regenerative Medicine: An Updated Review.Pharmaceutics · 2023Review
- Adjusting the physico-chemical properties of collagen scaffolds to accommodate primary osteoblasts and endothelial cells.Regenerative biomaterials · 2023Article
- Physicochemical properties and cell proliferation and adhesive bioactivity of collagen-hyaluronate composite gradient membrane.Frontiers in bioengineering and biotechnology · 2023Article
- Analysis of Three-Dimensional Cell Migration in Dopamine-Modified Poly(aspartic acid)-Based Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold.International journal of molecular sciences · 2021Article
- The recent advances in scaffolds for integrated periodontal regeneration.Bioactive materials · 2021Review
- Current Insights into Collagen Type I.Polymers · 2021Review
- Current Trends in In Vitro Modeling to Mimic Cellular Crosstalk in Periodontal Tissue.Advanced healthcare materials · 2021Review
- Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review.Polymers · 2020Review
- Generation of a three-dimensional collagen scaffold-based model of the human endometrium.Interface focus · 2020Article
- Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration.Pharmaceutics · 2020Review
- Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro.Matrix biology : journal of the International Society for Matrix Biology · 2020Article
- The Number of Platelets in Patient's Blood Influences the Mechanical and Morphological Properties of PRP-Clot and Lysophosphatidic Acid Quantity in PRP.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Design of cell-free scaffolds for endogenous cell recruitment requires an intimate knowledge of precise relationships between structure and biological function. Here, we use morphological analysis by Micro-CT to identify the key structural features necessary for periodontal ligament fibroblast recruitment into collagen scaffolds. By the combined use of time-lapse imaging and end-point invasion analysis, we distinguish the influences of pore size, pore wall alignment, and pore transport pathways (percolation diameter) on the individual cell migration and bulk invasion characteristics of these fibroblasts. Whereas maximising percolation diameter increased individual cell speed, elongation and directionality, and produced the most rapid bulk cell invasion, a pore size of 100 μm was found to be necessary to ensure an even distribution of cells across the scaffold cross-section. These results demonstrate that control of percolation diameter and pore size may be used respectively to tune the efficiency and uniformity of invasion through macroporous scaffolds. Crucially, however, these observations were subject to the condition of pore wall alignment, with low alignment in the direction of travel producing relatively low cell speeds and limited invasion in all cases. Pore wall alignment should therefore be carefully optimised in the design of scaffolds for cell recruitment, such as that required for periodontal ligament regeneration, as a key determining factor for cell movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.