Evidence map›Paper›PMID 30391953›Full record

ArticleDementia and geriatric cognitive disorders2018

Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old.

Christina G Wong, Kelsey R Thomas, Emily C Edmonds, Alexandra J Weigand, Katherine J Bangen, Joel S Eppig, Amy J Jak, Sherral A Devine, Lisa Delano-Wood, David J Libon and 3 more

Abstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Mild cognitive impairment in amyotrophic lateral sclerosis: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christina G WongVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Kelsey R ThomasVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Emily C EdmondsVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Alexandra J WeigandVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Katherine J BangenVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Joel S EppigSan Diego State University/University of California, San Diego (SDSU/UCSD) Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.
Amy J JakVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
Sherral A DevineThe Framingham Heart Study, Framingham, Massachusetts, USA.
Lisa Delano-WoodVeteran Affairs San Diego Healthcare System, San Diego, California, USA.
David J LibonDepartment of Geriatrics and Gerontology and the Department of Psychology, School of Osteopathic Medicine, New Jersey Institute for Successful Aging, Rowan University, Glassboro, New Jersey, USA.
Steven D EdlandDepartment of Biostatistics, University of California, San Diego, La Jolla, California, USA.
Rhoda AuThe Framingham Heart Study, Framingham, Massachusetts, USA.
Mark W BondiVeteran Affairs San Diego Healthcare System, San Diego, California, USA, mbondi@ucsd.edu.

Funding

EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Neuroimaging and Risk Factor Correlates in Aging and MCIK24AG026431 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W · 2007 to 2016
$1.7M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
Cognitive and Biomarker Profiles of Accurate and Inaccurate MCI DiagnosisIK2CX001415 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI EDMONDS, EMILY CHARLOTTE · 2017 to 2021
–
Neuroimaging and Vascular Correlates of Mild Cognitive Impairment SubtypesIK2CX000938 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BANGEN, KATHERINE · 2015 to 2019
–
CSRD VA IK2 CX000938CSRD VA IK2 CX001415NHLBI NIH HHS N01 HC025195NIA NIH HHS K24 AG026431NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG049810
6 · The paper itself

Abstract

BACKGROUND/

aimsMild cognitive impairment (MCI) lacks a "gold standard" operational definition. The Jak/Bondi actuarial neuropsychological criteria for MCI are associated with improved diagnostic stability and prediction of progression to dementia compared to conventional MCI diagnostic approaches, although its utility in diagnosing MCI in old-old individuals (age 75+) is unknown. Therefore, we investigated the applicability of neuropsychological MCI criteria among old-old from the Framingham Heart Study.

methodsA total of 347 adults (ages 79-102) were classified as cognitively normal or MCI via Jak/Bondi and conventional Petersen/Winblad criteria, which differ on cutoffs for cognitive impairment and number of impaired scores required for a diagnosis. Cox models examined MCI status in predicting risk of progression to dementia.

resultsMCI diagnosed by both the Jak/Bondi and Petersen/Winblad criteria was associated with incident dementia; however, when both criteria were included in the regression model together, only the Jak/Bondi criteria remained statistically significant. At follow-up, the Jak/Bondi criteria had a lower MCI-to-normal reversion rate than the Petersen/Winblad criteria.

conclusionsOur findings are consistent with previous research on the Jak/Bondi criteria and support the use of a comprehensive neuropsychological diagnostic approach for MCI among old-old individuals.

Indexed as

Cognitive DysfunctionDementiaAgedAged, 80 and overAgingDisease ProgressionFemaleGeriatric AssessmentHumansLongitudinal StudiesMaleNeuropsychological TestsPredictive Value of TestsProportional Hazards ModelsReproducibility of ResultsCognitive deficitsDementiaDiagnostic criteriaMild cognitive impairmentNeuropsychology

Identifiers

PMID30391953
PMCPMC9049857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.