ArticleDrug and alcohol dependence2019
Reward and executive control network resting-state functional connectivity is associated with impulsivity during reward-based decision making for cocaine users.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Adaptations of the balloon analog risk task for neuroimaging settings: a systematic review.Frontiers in neuroscience · 2023Pooled it
- Risk-taking in the human brain: An activation likelihood estimation meta-analysis of the balloon analog risk task (BART).Human brain mapping · 2022Pooled it
- Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review.Psychopharmacology · 2020Pooled it
- Meta-analytic clustering dissociates brain activity and behavior profiles across reward processing paradigms.Cognitive, affective & behavioral neuroscience · 2020Pooled it
- Differential Effects of Substance Use on HIV Care and Symptom Outcomes: A Longitudinal Analysis Among People with HIV.AIDS patient care and STDs · 2025Trial
- Brain connectomics markers for response prediction to transcranial magnetic stimulation in cocaine use disorder.Scientific reports · 2025Trial
- A double-blind sham-controlled phase 1 clinical trial of tDCS of the dorsolateral prefrontal cortex in cocaine inpatients: Craving, sleepiness, and contemplation to change.The European journal of neuroscience · 2021Trial
- Prefrontal-centered cortical alterations and network dysconnectivity in cocaine use disorder.Frontiers in psychiatry · 2026Article
- Altered integrated and segregated states in cocaine use disorder.Frontiers in neuroscience · 2025Article
- Hub disruption in HIV disease and cocaine use: A connectomics analysis of brain function.Drug and alcohol dependence · 2024Article
- Topological features of functional brain networks and subclinical impulsivity: an investigation in younger and older adults.Brain structure & function · 2024Article
- Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response.Nature. Mental health · 2024Article
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants.NMR in biomedicine · 2024Article
- The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research.Current addiction reports · 2024Review
- Common and distinct drug cue reactivity patterns associated with cocaine and heroin: An fMRI meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The perception of Mandarin speech conveying communicative functions in Chinese heroin addicts.PloS one · 2024Article
- Cocaine Use Prediction With Tensor-Based Machine Learning on Multimodal MRI Connectome Data.Neural computation · 2023Article
- Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto-parietal network in adolescents with internet addiction.Brain and behavior · 2023Article
- Whole-brain resting-state connectivity underlying impaired inhibitory control during early versus longer-term abstinence in cocaine addiction.Molecular psychiatry · 2023Article
- A generalizable functional connectivity signature characterizes brain dysfunction and links to rTMS treatment response in cocaine use disorder.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCocaine addiction is related to impulsive decision making that is mediated by brain circuitry involved in reward processing and executive functions, such as cognitive control and attentional salience. Resting-state functional connectivity between reward and executive control circuitry is altered among cocaine users, with concomitant deficits in impulsivity and learning. Prior research has examined how select brain regions interact to influence impulsive decision making for drug users; however, research examining interactions between large-scale brain networks and impulsive behavior is limited.
methodsThe current study compared reward and executive control network resting-state functional connectivity and its relationship to impulsive decision making between cocaine users (n = 37) and non-cocaine using control participants (n = 35). Participants completed computerized decision-making tasks and a separate resting-state functional magnetic resonance imaging scan. Data underwent independent component, dual regression, and linear regression moderation analyses.
resultsHigher impulsivity on the Balloon Analogue Risk Task (BART) was associated with inverse resting-state connectivity between the left cognitive control and subgenual anterior cingulate extended reward networks for cocaine users, while the opposite was found for controls. Less impulsivity on the monetary choice questionnaire was associated with stronger positive resting-state connectivity between the attentional salience and striatal core reward networks for controls, while cocaine users showed no association between impulsivity and resting-state connectivity of these networks.
conclusionsCocaine users show aberrant associations between reward-executive control resting-state network coupling and impulsive decision making. The findings support the conclusion that an imbalance between reward and executive control circuitry contributes to impulsivity in drug use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.