Evidence map›Paper›PMID 30391829›Full record

ArticleDomestic animal endocrinology2019

Placental development during early pregnancy in sheep: nuclear estrogen and progesterone receptor mRNA expression in the utero-placental compartments.

Anna T Grazul-Bilska, Soumi Bairagi, Aree Kraisoon, Sheri T Dorsam, Arshi Reyaz, Chainarong Navanukraw, Pawel P Borowicz, Lawrence P Reynolds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Domestic animal endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Programming of Embryonic Development.International journal of molecular sciences · 2021
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Anna T Grazul-BilskaDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA. Electronic address: Anna.Grazul-Bilska@ndsu.edu.
Soumi BairagiDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA.
Aree KraisoonDepartment of Animal Science, Agricultural Biotechnology Research Center for Sustainable Economy (ABRCSE), Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand; Center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand.
Sheri T DorsamDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA.
Arshi ReyazDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA.
Chainarong NavanukrawDepartment of Animal Science, Agricultural Biotechnology Research Center for Sustainable Economy (ABRCSE), Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand; Center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand.
Pawel P BorowiczDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA.
Lawrence P ReynoldsDepartment of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA.
North Dakota State University · USKhon Kaen University · TH

Funding

Steroid Receptors in Placental Tissue and Vasculature during Early PregnancyR03HD076073 · NICHD · NORTH DAKOTA STATE UNIVERSITY · PI GRAZUL-BILSKA, ANNA T, REYNOLDS, LAWRENCE P · 2014 to 2015
$143k
NICHD NIH HHS R03 HD076073
6 · The paper itself

Abstract

Sex steroid hormones are major regulators of uterine and placental growth and functions, as well as many other biological processes. To examine the mRNA expression of nuclear estrogen (ESR1 and 2) and progesterone (PGRAB and B) receptors in different compartments of the uterus and placenta, tissues were collected in experiment 1 on days 16, 20, and 28 after natural mating (NAT) and on day 10 after estrus (nonpregnant controls [NP]); and in experiment 2 on day 22 of NAT, and pregnancies established after transfer of embryos generated through mating of FSH-treated ewes (NAT-ET), in vitro fertilization (IVF), or in vitro activation (parthenotes). In experiment 1, ESR1 expression in endometrial stroma (ES), endometrial glands (EGs), and myometrial blood vessels (MBVs), ESR2 in endometrial blood vessels (EBV), PGRAB in ES, and PGRB in ES, EG, and MBV was greater in pregnant than NP ewes depending on the day of pregnancy. The day of pregnancy affected the expression of ESR1 in MBV, ESR2 in EBV and MBV, and PGRAB in ES. In experiment 2, ESR1, PGRAB, and PGRB in EG, but not in other compartments, was greater in NAT-ET than NAT, and PGRB was greater for NAT-ET than IVF. These data demonstrate that ESR and PGR expression differ in pregnant versus NP ewes in selected compartments and was affected by pregnancy stage or embryo origin in selected utero-placental compartments. Thus, sex steroid hormone mRNA expression is differentially regulated in a spatiotemporal manner in the uterus and placenta and is affected by the application of assisted reproductive technology in sheep.

Indexed as

Gene Expression RegulationAnimalsEmbryo TransferEstrogen Receptor alphaEstrogen Receptor betaFemaleFertilization in VitroFollicle Stimulating HormoneGestational AgePlacentaPlacentationPregnancyReceptors, EstrogenReceptors, ProgesteroneRNA, MessengerSheepEstrogen Receptor alphaEstrogen Receptor betaFollicle Stimulating Hormoneprogesterone receptor Aprogesterone receptor BReceptors, EstrogenReceptors, ProgesteroneRNA, MessengerAssisted reproductive technologyLaser capture microdissectionSex steroid receptors mRNASheepUterine and placental compartments

Identifiers

PMID30391829
PMCPMC6281792
OpenAlexW2893415927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.