ArticleNeuropsychologia2019
Multimodal neuroimaging evidence for looser lexico-semantic networks in schizophrenia:Evidence from masked indirect semantic priming.
Article in Neuropsychologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms.Frontiers in psychiatry · 2024Pooled it
- Fixation-related potentials reveal that confusing program code elicits a late frontal positivity.Scientific reports · 2026Article
- Linguistic findings in persons with schizophrenia-a review of the current literature.Frontiers in psychology · 2023Review
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- Progressive changes in descriptive discourse in First Episode Schizophrenia: a longitudinal computational semantics study.Schizophrenia (Heidelberg, Germany) · 2022Article
- Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?Frontiers in neuroscience · 2021Article
- Impairments in Probabilistic Prediction and Bayesian Learning Can Explain Reduced Neural Semantic Priming in Schizophrenia.Schizophrenia bulletin · 2020Article
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7 authors.
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Abstract
It has been hypothesized that schizophrenia is characterized by overly broad automatic activity within lexico-semantic networks. We used two complementary neuroimaging techniques, Magnetoencephalography (MEG) and functional Magnetic Resonance Imaging (fMRI), in combination with a highly automatic indirect semantic priming paradigm, to spatiotemporally localize this abnormality in the brain. Eighteen people with schizophrenia and 20 demographically-matched control participants viewed target words ("bell") preceded by directly related ("church"), indirectly related ("priest"), or unrelated ("hammer") prime words in MEG and fMRI sessions. To minimize top-down processing, the prime was masked, the target appeared only 140 ms after prime onset, and participants simply monitored for words within a particular semantic category that appeared in filler trials. Both techniques revealed a significantly larger automatic indirect priming effect in people with schizophrenia than in control participants. MEG temporally localized this enhanced effect to the N400 time window (300-500 ms) - the critical stage of accessing meaning from words. fMRI spatially localized the effect to the left temporal fusiform cortex, which plays a role in mapping of orthographic word-form on to meaning. There was no evidence of an enhanced automatic direct semantic priming effect in the schizophrenia group. These findings provide converging neural evidence for abnormally broad highly automatic lexico-semantic activity in schizophrenia. We argue that, rather than arising from an unconstrained spread of automatic activation across semantic memory, this broader automatic lexico-semantic activity stems from looser mappings between the form and meaning of words.
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