Evidence map›Paper›PMID 30391471›Full record

ArticleGastroenterology2019

MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils.

Qing Yang, Tomohiko Yasuda, Eunyoung Choi, Takeshi Toyoda, Joseph T Roland, Eiji Uchida, Hiroshi Yoshida, Yasuyuki Seto, James R Goldenring, Sachiyo Nomura

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Qing YangInstitute of Pathogen Biology, School of Basic Medical Sciences, Shandong University, Jinan, China; Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Tomohiko YasudaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Gastrointestinal Surgery, Graduate School, Nippon Medical School, Tokyo, Japan.
Eunyoung ChoiDepartment of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Nashville Veterans Affairs Medical Center, Nashville, Tennessee.
Takeshi ToyodaDivision of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Joseph T RolandDepartment of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Nashville Veterans Affairs Medical Center, Nashville, Tennessee.
Eiji UchidaDepartment of Gastrointestinal Surgery, Graduate School, Nippon Medical School, Tokyo, Japan.
Hiroshi YoshidaDepartment of Gastrointestinal Surgery, Graduate School, Nippon Medical School, Tokyo, Japan.
Yasuyuki SetoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
James R GoldenringDepartment of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Nashville Veterans Affairs Medical Center, Nashville, Tennessee. Electronic address: jim.goldenring@vanderbilt.edu.
Sachiyo NomuraDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: snomura-gi@umin.ac.jp.
Vanderbilt University · USNippon Medical School · JPThe University of Tokyo · JPNational Institute of Health Sciences · JPNippon Medical School Hospital · JPShandong University · CN

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Induction and Evolution of Metaplasia in the StomachR01DK101332 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eunyoung Choi, James Richard Goldenring · 2014 to 2026
$5.9M
Mechanisms of Gastric Mucous Cell MetaplasiaR01DK071590 · NIDDK · VANDERBILT UNIVERSITY · PI GOLDENRING, JAMES RICHARD · 2008 to 2012
$2.2M
Oxyntic Atrophy and Novel Gastric Lineages.I01BX000930 · VA · VETERANS HEALTH ADMINISTRATION · PI GOLDENRING, JAMES RICHARD · 2011 to 2025
–
Ariol SL200 Digital Imaging SystemIS1BX003097 · VA · VETERANS HEALTH ADMINISTRATION · PI GOLDENRING, JAMES RICHARD · 2015 to 2015
–
BLRD VA I01 BX000930BLRD VA IS1 BX003097NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK071590NIDDK NIH HHS R01 DK101332
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcrylonitrileAniline CompoundsAnimalsBenzimidazolesBiopsy, NeedleDisease Models, AnimalGastric MucosaGerbillinaeHelicobacter InfectionsHelicobacter pyloriImmunohistochemistryMaleMetaplasiaRandom AllocationReference ValuesTreatment OutcomeAcrylonitrileAniline CompoundsAZD 6244BenzimidazolesMEK inhibitor I

Identifiers

PMID30391471
PMCPMC6368860
OpenAlexW2899336666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.