Evidence map›Paper›PMID 30391420›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2019

Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe.

Evgeniya Sovershaeva, Tinei Shamu, Tom Wilsgaard, Tsitsi Bandason, Trond Flægstad, David Katzenstein, Rashida A Ferrand, Jon Odland

Open access · goldAbstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Clinical Outcomes in a Randomized Controlled Trial Comparing Point-of-Care With Standard Human Immunodeficiency Virus (HIV) Viral Load Monitoring in Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Evgeniya SovershaevaDepartment of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway. Electronic address: evgeniya.sovershaeva@uit.no.
Tinei ShamuNewlands Clinic, Harare, Zimbabwe.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
Tsitsi BandasonBiomedical Research and Training Institute, Harare, Zimbabwe.
Trond FlægstadDepartment of Paediatrics, University Hospital of North Norway, Tromsø, Norway.
David KatzensteinDivision of Infectious Diseases, Stanford University, California, USA.
Rashida A FerrandBiomedical Research and Training Institute, Harare, Zimbabwe; Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.
Jon OdlandDepartment of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU The Norwegian University of Science and Technology, Trondheim, Norway.
UiT The Arctic University of Norway · NOBiomedical Research and Training Institute · ZWLondon School of Hygiene & Tropical Medicine · GBNorwegian University of Science and Technology · NOStanford University · USUniversity Hospital of North Norway · NO

Funding

Wellcome Trust 206316Wellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

objectiveTo investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.

methodsChildren (0-19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral blips were assessed and the predictors of viraemia were determined using logistic and parametric survival regression analyses.

resultsA total of 630 individuals initiated ART, and 19.7% of children and 5.6% of adults did not achieve viral suppression by 12 months. Younger age and CD4 count ≤200 cells/mm

conclusionsChildren are less likely to reach viral suppression and are at higher risk of viraemia while on ART than adults. The significance of LLV and blips needs further study.

Indexed as

AdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountChildChild, PreschoolFemaleHIV InfectionsHumansIncidenceMaleRetrospective StudiesViral LoadViremiaZimbabweAnti-HIV AgentsAntiretroviral therapyHIVSub-Saharan AfricaViraemiaViral blipViral load

Identifiers

PMID30391420
PMCPMC7614873
OpenAlexW2898678482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.