Evidence map›Paper›PMID 30391394›Full record

ReviewOsteoarthritis and cartilage2019

Models of osteoarthritis: the good, the bad and the promising.

P J Cope, K Ourradi, Y Li, M Sharif

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03783455 (Assessment of Short-term Effectiveness of Five Local Treatment Modalities in Patients With Symptomatic Knee Osteoarthritis), which is not on this map. Cited by 129 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03783455 nacompletednot on this map

Assessment of Short-term Effectiveness of Five Local Treatment Modalities in Patients With Symptomatic Knee Osteoarthritis: a Randomized Prospective Study

TypeinterventionalSponsorMaimónides Biomedical Research Institute of CórdobaRan2015 to 2016Enrolled150ConditionsOsteo Arthritis KneeArmsNon arthroscopic joint lavage, Non arthroscopic joint lavage plus corticosteroid, Non arthroscopic joint lavage plus hyaluronic acid, Intraarticular injection of corticosteroid, Intraarticular injection of hyaluronic acid
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. TNFα-Related Chondrocyte Inflammation Models: A Systematic Review.International journal of molecular sciences · 2024
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

P J CopeMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building Level 2, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: pc14080@my.bristol.ac.uk.
K OurradiMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building Level 2, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: Khadija.ourradi@bristol.ac.uk.
Y LiMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building Level 2, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: Yunfei.Li@bristol.ac.uk.
M SharifMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning and Research Building Level 2, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: mo.sharif@bristol.ac.uk.

Funding

Arthritis Research UK 20406
6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly affecting people over the age of forty. The causes of OA are still unknown and there is much debate in the literature as to the exact sequence of events that trigger the onset of the heterogeneous disease we recognise as OA. There is currently no consensus model for OA that naturally reflects human disease. Existing ex-vivo models do not incorporate the important inter-tissue communication between joint components required for disease progression and differences in size, anatomy, histology and biomechanics between different animal models makes translation to the human model very difficult. This narrative review highlights the advantages and disadvantages of the current models used to study OA. It discusses the challenges of producing a more reliable OA-model and proposes a direction for the development of a consensus model that reflects the natural environment of human OA. We suggest that a human osteochondral plug-based model may overcome many of the fundamental limitations associated with animal and in-vitro models based on isolated cells. Such a model will also provide a platform for the development and testing of targeted treatment and validation of novel OA markers directly on human tissues.

Indexed as

AnimalsArthritis, ExperimentalBiomedical ResearchBone TransplantationCell Culture TechniquesHumansOsteoarthritisSpecies SpecificityAnimal-modelex-vivo modelin-vivo modelOsteoarthritisOsteochondral plugs

Identifiers

PMID30391394
PMCPMC6350005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.