Evidence map›Paper›PMID 30390900›Full record

ReviewThe journal of allergy and clinical immunology. In practice

Environmental Food Exposure: What Is the Risk of Clinical Reactivity From Cross-Contact and What Is the Risk of Sensitization.

William J Sheehan, Steve L Taylor, Wanda Phipatanakul, Helen A Brough

Abstract readReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Immuno-PCR in the Analysis of Food Contaminants.International journal of molecular sciences · 2025
    Review
  4. Article
  5. TrackingBiosensors · 2022
    Article
  6. Article
  7. The External Exposome and Food Allergy.Current allergy and asthma reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William J SheehanThe Division of Allergy and Immunology, Children's National Medical Center, Washington, DC; George Washington University School of Medicine and Health Sciences, Washington, DC; The Division of Allergy and Immunology, Boston Children's Hospital, Boston, Mass. Electronic address: wsheehan@childrensnational.org.
Steve L TaylorFood Allergy Research and Resource Program, Department of Food Science and Technology, University of Nebraska, Lincoln, Neb.
Wanda PhipatanakulThe Division of Allergy and Immunology, Boston Children's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
Helen A BroughPaediatric Allergy Group, Department of Women and Children's Health, School of Life Course Sciences, King's College London, Guy's Hospital, London, United Kingdom; Paediatric Allergy Group, School of Immunology & Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom; Children's Allergy Service, Evelina London, St Thomas' Hospital, London, United Kingdom.

Funding

SICAS- Diversity SupplementU01AI110397 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2015 to 2020
$8.8M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Role of Peanut Allergen in Urban Schools and PreschoolsK23AI104780 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI SHEEHAN, WILLIAM JAMES · 2014 to 2018
$912k
Department of HealthNIAID NIH HHS K23 AI104780NIAID NIH HHS K24 AI106822NIAID NIH HHS L40 AI107923NIAID NIH HHS U01 AI110397
6 · The paper itself

Abstract

For food-allergic individuals, the typical exposure to food proteins happens during ingestion; however, individuals may be exposed to foods in other ways. In addition to ingestion reactions, allergic patients may have reactions from cutaneous or mucosal exposures to food proteins, with the classic example being a peanut-allergic child touching a counter with peanut butter and then rubbing their eyes. Similar to hands, saliva can also act as a carrier for food proteins. Finally, there is a wealth of new research regarding the presence of food proteins in the environment, for example, within household floor dust. This review will focus on (1) cross-contact of food proteins and (2) environmental food protein exposures. Cross-contact occurs when one type of food comes into contact with another type of food resulting in the mixture of proteins. For food allergies, cross-contact is important when an allergen is inadvertently transferred to a food/meal that is thought to not contain that specific allergen. We will discuss the current literature regarding the presence of detectable food proteins in different locations, how and if these proteins are transferred or eliminated, and the clinical implications of exposures to food proteins under these different scenarios.

Indexed as

AllergensEnvironmental ExposureFoodDietary ProteinsFood HypersensitivityHumansRiskAllergensDietary ProteinsCross-contactEnvironmentFood allergyHousehold dustPeanut allergy

Identifiers

PMID30390900
PMCPMC6324195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.