Evidence map›Paper›PMID 30390764›Full record

ReviewHematology/oncology clinics of North America2018

Early Detection of Ovarian Cancer.

Kevin M Elias, Jing Guo, Robert C Bast

Registry-linked trialAbstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05697601 (Associated Factors of Ovarian Cancer and Endometrial Cancer in Indonesia. A Study for Developing Artificial-Intelligence-Based Screening Tools), which is not on this map. Cited by 119 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 3 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05697601 unknown statusnot on this mapstarted 2023, after this paper: background citation

Associated Factors of Ovarian Cancer and Endometrial Cancer in Indonesia. A Study for Developing Artificial-Intelligence-Based Screening Tools

TypeobservationalSponsorHasanuddin UniversityRan2023 to 2024Enrolled2,905ConditionsOvarian Cancer, Endometrial Cancer, Endometrial HyperplasiaArmsArtificial-Intelligence Based Screening Tools, Pathology analysis
3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  11. Review
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  15. Review
  16. Article
  17. Bidirectional Association between Atrial Fibrillation and Ovarian Cancer: Evidence from the UK Biobank and Mendelian Randomization.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  18. Article
  19. Review
  20. Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Kevin M EliasDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: kelias@bwh.harvard.edu.
Jing GuoDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, Tongji University, 301 Yanchang Road, Jingan, Shanghai 200072, China.
Robert C BastDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Dana-Farber Brigham Cancer Center · USShanghai Tenth People's Hospital · CNThe University of Texas MD Anderson Cancer Center · US

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
MD Anderson Cancer Center EDRN- CVC for Early Detection of Ovarian CancerU01CA200462 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ROBERT C BAST · 2016 to 2026
$9.3M
NCI NIH HHS P50 CA083639NCI NIH HHS U01 CA200462NICHD NIH HHS K12 HD000849
6 · The paper itself

Abstract

Early detection of ovarian cancer could reduce mortality by 10% to 30%. Effective screening requires high sensitivity (>75%) and extremely high specificity (99.7%). Clinical trials suggest the best specificity is achieved with 2-stage strategies in which increasing serum CA125 level triggers transvaginal sonography to detect a malignant pelvic mass, although evidence for such approaches improving overall survival has been limited. Screening may be improved by combining CA125 with novel biomarkers, such as autoantibodies, circulating tumor DNA, or microRNAs. In order to detect premetastatic ovarian cancers originating in the distal fallopian tube, more sensitive approaches to diagnostic imaging are required.

Indexed as

Ovarian NeoplasmsAnimalsBiomarkers, TumorEarly Detection of CancerFemaleHumansBiomarkers, TumorAutoantibodiesCA125ctDNAEarly detectionmiRNAOvarian cancerScreeningTP53

Identifiers

PMID30390764
PMCPMC6376972
OpenAlexW2893656853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.