Evidence map›Paper›PMID 30390740›Full record

ReviewClinics in chest medicine2018

Inflammation and Pneumonia: Why Are Some More Susceptible than Others?

Joseph P Mizgerd

Abstract readReview
In one paragraph

Review in Clinics in chest medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. SomaticiScience · 2025
    Article
  8. Research Progress on Anti-Inflammatory Mechanism ofInternational journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Glucocorticoid Therapy in COVID-19.Seminars in respiratory and critical care medicine · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Joseph P MizgerdPulmonary Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02115, USA. Electronic address: jmizgerd@bu.edu.
Boston University · US

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Pneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6M
Lung-resident antibacterial heterotypic immunityR01AI115053 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2015 to 2023
$4.0M
Macrophage protection in pneumococcal pneumoniaR56AI122763 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2016 to 2016
$640k
The B cell repertoire as a window into the nature and impact of the lung viromeR61HL137081 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, KEPLER, THOMAS B · 2017 to 2018
$565k
NHLBI NIH HHS R35 HL135756NHLBI NIH HHS R61 HL137081NHLBI NIH HHS T32 HL007035NIAID NIH HHS R01 AI115053NIAID NIH HHS R56 AI122763
6 · The paper itself

Abstract

Pneumonia is an important cause of morbidity and mortality. However, pneumonia is an unusual outcome of respiratory infection. Most of the time, microbes in the lung can be controlled by a combination of constitutive and recruited defense mechanisms. Inflammation is a key component of recruited defenses. Variations in inflammation that influence pneumonia susceptibility and severity are considered here.

Indexed as

HumansInflammationLungPneumoniaRespiratory Tract InfectionsCytokinesEpithelial cellsInnate lymphocytesMacrophagesNeutrophilsNF-κBPneumococcusResident memory cells

Identifiers

PMID30390740
PMCPMC6221464
OpenAlexW2899099099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.