ArticleBreast cancer research : BCR2018
Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sensitive Period Analysis of Adulthood BMI and Cancer Risk: An Individual Participant Data Meta-Analysis of Over 720,000 Participants in the ABACus 2 Consortium.International journal of cancer · 2026Pooled it
- Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic.British journal of cancer · 2023Trial
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- The Role of Angiogenesis in Breast Cancer and Obesity: Unravelling the Connection.International journal of breast cancer · 2026Review
- CT-based body composition and its demographic and clinical associations in women aged 20 to 40 with non-metastatic breast cancer.Scientific reports · 2025Article
- Breast Cancer Awareness and Knowledge Among Women at a Municipal Hospital in Ghana: A Cross-Sectional Study.Cancer reports (Hoboken, N.J.) · 2025Article
- Advancing environmental epidemiologic methods to confront the cancer burden.American journal of epidemiology · 2025Article
- Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk.JNCI cancer spectrum · 2025Article
- Early breast cancer in youngTherapeutic advances in medical oncology · 2025Review
- Breast and bowel cancers diagnosed in people 'too young to have cancer': A blueprint for research using family and twin studies.Genetic epidemiology · 2024Article
- Article
- Synchronous or metachronous breast and colorectal cancers in younger-than-average-age patients: a case series.The oncologist · 2024Article
- Synchronous Breast and Colorectal Malignant Tumors-A Systematic Review.Life (Basel, Switzerland) · 2024Review
- Weight, weight gain and behavioural risk factors in women attending a breast cancer family history, risk and prevention clinic: an observational study.BJC reports · 2024Article
- Variance of age-specific log incidence decomposition (VALID): a unifying model of measured and unmeasured genetic and non-genetic risks.International journal of epidemiology · 2023Article
- Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science.Cold Spring Harbor perspectives in medicine · 2023Review
- Review
- Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.Breast cancer research : BCR · 2023Article
- Update Breast Cancer 2023 Part 1 - Early Stage Breast Cancer.Geburtshilfe und Frauenheilkunde · 2023Article
- Validation of an Abridged Breast Cancer Risk Prediction Model for the General Population.Cancer prevention research (Philadelphia, Pa.) · 2023Article
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Authors and funding
24 authors.
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Abstract
backgroundThe association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk.
methodsWe conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline.
resultsThe strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk.
conclusionsThe greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.
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