ArticleActa veterinaria Scandinavica2018
Epidemiological assessment of the risk of canine mast cell tumours based on the Kiupel two-grade malignancy classification.
Article in Acta veterinaria Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Epidemiology of Four Major Canine Tumours in the UK: Insights From a National Pathology Registry With Comparative Oncology Perspectives.Veterinary and comparative oncology · 2026Article
- CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX-5+ Tumour-Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours.Veterinary and comparative oncology · 2026Article
- The Characteristics of 924 Cutaneous Mast Cell Tumours in Dogs ≤ 3 Years of Age-With a Short Literature Review of Feline, Equine, and Human Proliferative Mast Cell Disorders.Veterinary sciences · 2026Article
- Revisiting Ki-67 Assessment in Canine Mast Cell Tumours: From Manual Hotspot to Automated Global Analysis.Veterinary sciences · 2026Article
- The microenvironment in canine mast cell tumors: association between tumor-associated tissue eosinophilia and histological grade.Frontiers in veterinary science · 2026Article
- Cutaneous mast cell tumors in dogs: Association with gonadectomy.Brazilian journal of veterinary medicine · 2026Article
- Retrospective Analysis of Prevalence of Tumors in Dogs and Cats in Lithuania.Veterinary sciences · 2025Article
- Suspected canine primary lymph node mast cell tumor.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Article
- Tracheal mast cell tumor in a dog - surgical approach and diagnosis.Brazilian journal of veterinary medicine · 2025Article
- Preputial and scrotal cutaneous mast cell tumors in dogs show no evidence of inherently higher biologic malignancy.Frontiers in veterinary science · 2025Article
- The Use of Sentinel Lymph Node Mapping for Canine Mast Cell Tumors.Animals : an open access journal from MDPI · 2024Review
- Clinical outcomes of dogs with high-grade cutaneous mast cell tumors.Frontiers in veterinary science · 2024Article
- Psychological Stress Is Associated with Increased Cancer Risk in Dogs.Animals : an open access journal from MDPI · 2023Article
- Canine mast cell tumours part I: Clinical and survival outcomes.Veterinary medicine and science · 2022Article
- Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors.Cells · 2022Review
- Plasma small extracellular vesicles from dogs affected by cutaneous mast cell tumors deliver high levels of miR-21-5p.Frontiers in veterinary science · 2022Article
- Article
- Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC-46).Journal of veterinary internal medicine · 2021Article
- Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal.Frontiers in veterinary science · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe degree of differentiation of mast cell tumours (MCTs) is the most important feature and reflects the morphological characteristics and metastatic potential of the tumour and its likely response to treatment and the prognosis. The aim of this study was to epidemiologically analyse the risk of MCT development in dogs according to breed, age, sex, size and anatomical location of the tumour using the Kiupel grading system. The analysis involved 492 dogs selected based on a histopathological assessment of 2763 canine skin tumours. A logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals.
resultsMast cell tumours accounted for 17.8% of all diagnosed canine skin tumours. The highest risk of high-grade MCTs was noted in the Shar-Pei (OR 28.18, P < 0.001) and Weimaraner (OR 6.45, P = 0.023). The highest risk of low-grade MCTs was determined in the Boxer (OR 6.72, P < 0.001), and Pug (OR 6.13, P = 0.027). The scrotum (OR 31.72, P < 0.001), inguinal area (OR 17.69, P < 0.001) and axilla (OR 6.30, P < 0.001) had the highest risk of high-grade MCTs. The risk of high-grade MCTs increased with age and peaked in the oldest dogs, aged 11-16 years (OR 9.55, P < 0.001). A higher risk of low-grade tumours was noted in younger dogs (aged 4-6 years) (OR 8.54, P < 0.001) and females (OR 1.43, P = 0.001). Statistical analysis further revealed a higher risk of both low (OR 3.47, P < 0.001) and high-grade MCTs (OR 1.71, P = 0.006) in medium-sized dogs.
conclusionsThis study demonstrated relationships between Kiupel grading system and phenotypic traits, age and location of canine MCTs confirming the complex biological nature of this tumour.
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