Evidence map›Paper›PMID 30390679›Full record

ArticleJournal of neuroinflammation2018

CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau.

Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N G Nilsson, Leiv Otto Watne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kristi HenjumDepartment of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, P.O. box 1057 Blindern, 0316, Oslo, Norway. kristi.henjum@medisin.uio.no.
Else Quist-PaulsenDepartment of Infectious Diseases, Oslo University Hospital, Ullevaal Hospital, P.O. Box 4956 Nydalen, N-0450, Oslo, Norway.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, SE-431 80, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, SE-431 80, Mölndal, Sweden.
Lars N G NilssonDepartment of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, P.O. box 1057 Blindern, 0316, Oslo, Norway.
Leiv Otto WatneOslo Delirium Research Group, Department of Geriatric Medicine, Oslo University Hospital, PO box 4950 Nydalen, N-0424, Oslo, Norway.
University of Oslo · NOUniversity of Gothenburg · SEOslo University Hospital · NO

Funding

Helse Sør-Øst RHF 2013016
6 · The paper itself

Abstract

backgroundDelirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dementia and neurodegenerative disease. It encodes expression of an innate immune receptor in the brain expressed by microglia. The level of the soluble fragment of TREM2 (sTREM2) is reported to increase in the cerebrospinal fluid (CSF) already in prodromal and asymptomatic Alzheimer's disease.

methodsWe analyzed the level of CSF sTREM2 in relation to delirium and dementia. The study included patients with or without pre-existing dementia who underwent acute hip fracture surgery (n = 120), and some of the patients developed delirium (n = 65). A medical delirium cohort (n = 26) was also examined. ELISA was used to determine the level of sTREM2 in CSF.

resultsDelirium was associated with a higher level of CSF sTREM2 only among those without pre-existing dementia (p = 0.046, n = 15, n = 44), particularly among patients developing delirium after CSF sampling (p = 0.02, n = 7, n = 44). Between patients with dementia, there was no group difference, but the CSF sTREM2 level increased with waiting time for surgery (r

conclusionThe findings reinforce the involvement of neuroinflammation in delirium, yet with separate responses in patients with or without pre-existing dementia. Our findings support the concept of primed microglia in neurodegenerative disease and central immune activation after a peripheral trauma in such patients. A CSF biomarker panel of neuroinflammation might be valuable to prevent delirium by identifying patients at risk.

Indexed as

AgedAged, 80 and overAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesCohort StudiesDeliriumFemaleHip FracturesHumansMaleMembrane GlycoproteinsMiddle AgedPeptide FragmentsPhosphorylationPlaque, AmyloidAmyloid beta-Peptidesamyloid beta-protein (1-42)Membrane GlycoproteinsPeptide FragmentsReceptors, Immunologictau ProteinsTREM2 protein, humanAlzheimer’s diseaseCSF biomarkersDeliriumDementiaSoluble TREM2

Identifiers

PMID30390679
PMCPMC6215363
OpenAlexW2899108000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.