ArticleBMC ophthalmology2018
Cancer-associated retinopathy preceding the diagnosis of cancer.
Article in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Electronegative ERG in association with probable TRPM1-related cancer associated retinopathy: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Cancer-Associated Retinopathy in a Patient with Small Cell Lung Cancer and Esophageal Cancer: A Case Report.Korean journal of ophthalmology : KJO · 2025Article
- Diagnosis and treatment of autoimmune retinopathy: review of current approaches.International ophthalmology · 2025Review
- Cancer-Associated Retinopathy as the Sole Presenting Sign of Small Cell Lung Cancer: A Case Report.Cureus · 2025Article
- Clinical, electrophysiologic and serologic evidence of cancer associated retinopathy preceding a diagnosis of breast cancer.BMJ case reports · 2024Article
- What to expect from paraneoplastic syndromes of the nervous system in uterine cancer: A review of the literature.Gynecologic oncology reports · 2023Review
- Intravitreal Dexamethasone Implant in Autoimmune Retinopathy.Case reports in ophthalmological medicine · 2023Article
- Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report.American journal of ophthalmology case reports · 2022Article
- Paraneoplastic syndrome in neuroophthalmology.Journal of neurology · 2022Review
- Cancer-Associated Retinopathy due to Clear Cell Renal Carcinoma.Ocular oncology and pathology · 2021Article
- Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria.Frontiers in neurology · 2021Review
- Bilateral Paraneoplastic Vitritis: A Case Report.Beyoglu eye journal · 2021Article
- Ocular Paraneoplastic Syndromes.Biomedicines · 2020Review
- Cancer-associated retinopathy preceding the diagnosis of a pulmonary carcinoid tumour.BMJ case reports · 2020Article
- An update on autoimmune retinopathy.Indian journal of ophthalmology · 2020Review
- Cancer-associated retinopathy as an initial presentation of gynecologic small-cell carcinoma.Taiwan journal of ophthalmologyArticle
- Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early diagnosis of cancer is of crucial importance and a key prognostic factor. Cancer-associated retinopathy (CAR) can be symptomatic prior to other manifestations directly related to malignant tumors. The aim of this study was to show that, in selected cases, ophthalmic findings are consistent enough with the diagnosis of CAR to trigger investigations aimed at detecting a previously unknown malignancy.
methodsThis was a monocentric retrospective case series performed in a tertiary referral center. Patients with a diagnosis of CAR were included. Diagnosis was based on the clinical presentation, the visual field and electroretinogram alterations. The clinical presentation, visual field testing and electroretinographic results were analyzed as well as the malignancies identified following the diagnosis of CAR. Follow-up data was collected.
resultsFour patients (two men, two women, median age 65.5 years) were included. All patients presented with posterior segment inflammation at initial presentation as well as advanced visual field loss and an extinguished electroretinogram. The best corrected decimal visual acuity was 0.8 or better in both eyes of three patients and decreased to 0.3 OD and O.2 OS in one patient due to a bilateral macular edema. No patient had a previously known history of cancer. Once the diagnosis of CAR was made, investigations aimed at identifying a malignant tumors subsequently led to the diagnosis of two cases of small cell lung tumors, of one prostate carcinoma and of a uterine sarcoma. The treatment of CAR included plasmapheresis, systemic corticosteroids, azathioprine, cyclosporine and periocular or intraocular corticosteroid injections. In all cases the intraocular inflammation resolved, but pigment mottling, diffuse retinal atrophy, optic disc pallor and arterial narrowing were among manifestations observed during the follow-up of the patients.
conclusionIn selected patients, findings suggestive of CAR can be useful for the early detection of a cancer.
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