ArticleBMC immunology2018
Altered endotoxin responsiveness in healthy children with Down syndrome.
Article in BMC immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome.Clinical and experimental immunology · 2024Article
- Article
- Recurrent Respiratory Infections in Children with Down Syndrome: A Review.Children (Basel, Switzerland) · 2024Review
- Periodontal disease in down syndrome: Predisposing factors and potential non-surgical therapeutic approaches.Journal of clinical laboratory analysis · 2024Review
- Uncovering Novel Biomarkers of Inflammation as Potential Screening Targets of Disease Risk in Healthcare Shift Workers: A Pilot Study.International journal of nursing and health care research · 2023Article
- Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil.Human genetics · 2022Article
- Melatonin as an immunomodulator in children with Down syndrome.Pediatric research · 2022Article
- Methadone alters the peripheral inflammatory and central immune landscape following prenatal exposure in rats.Advances in drug and alcohol research · 2022Article
- Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation.International journal of environmental research and public health · 2021Article
- Specific Susceptibility to COVID-19 in Adults with Down Syndrome.Neuromolecular medicine · 2021Article
- Sustained peripheral immune hyper-reactivity (SPIHR): an enduring biomarker of altered inflammatory responses in adult rats after perinatal brain injury.Journal of neuroinflammation · 2021Article
- Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes.Frontiers in pediatrics · 2021Article
- Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia.Frontiers in pediatrics · 2020Article
- Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity.Frontiers in pediatrics · 2020Article
- Immune Dysregulation in Children With Down Syndrome.Frontiers in pediatrics · 2020Review
- Altered Toll-Like Receptor Signalling in Children with Down Syndrome.Mediators of inflammation · 2019Article
- Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.Frontiers in immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDown syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface markers upregulated in response to Lipopolysaccharide (LPS) endotoxin, and the immunomodulator melatonin. Neutrophil and monocyte responses to LPS and melatonin in children with Down syndrome (DS) who were clinically stable were compared to age-matched controls. Whole blood was incubated with LPS and melatonin and the relative expression of CD11b and TLR-4 evaluated by flow cytometry.
resultsChildren with DS had an increased response to LPS in neutrophils and intermediate monocytes, while also having elevated TLR-4 expression on non-classical monocytes compared to controls at baseline. Melatonin reduced CD11b expression on neutrophils, total monocytes, both classical and intermediate sub-types, in children with DS and controls.
conclusionMelatonin could represent a useful clinical adjunct in the treatment of sepsis as an immunomodulator. Children with DS had increased LPS responses which may contribute to the more adverse outcomes seen in sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.