ArticleNeurobiology of aging2019
Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06284720 (Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults), which is not on this map. Cited by 54 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults
Who cites it
54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Systematic review ofFrontiers in aging neuroscience · 2023Pooled it
- Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis.Alzheimer's research & therapy · 2022Pooled it
- Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies.Ageing research reviews · 2021Pooled it
- Meta-Analysis of Neurochemical Changes Estimated via Magnetic Resonance Spectroscopy in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Pooled it
- Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.The Journal of physiology · 2026Review
- GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment.Aging and disease · 2025Article
- MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- "Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.Translational psychiatry · 2025Article
- CEST imaging combined withAlzheimer's research & therapy · 2025Article
- Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression withNeurobiology of aging · 2024Article
- Neurometabolic topography and associations with cognition in Alzheimer's disease: A whole-brain high-resolution 3D MRSI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Predicting performance in attention by measuring key metabolites in the PCC with 7T MRS.Scientific reports · 2024Article
- Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory.NeuroImage · 2024Article
- Impact of acquisition and modeling parameters on the test-retest reproducibility of edited GABA.NMR in biomedicine · 2024Article
- Article
- Estimating the synaptic density deficit in Alzheimer's disease using multi-contrast CEST imaging.PloS one · 2024Article
- Investigating the brain's neurochemical profile at midlife in relation to dementia risk factors.Brain communications · 2024Article
- Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer's Disease: Role of Glutathione and Metal Ions.ACS chemical neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The levels of several brain metabolites were investigated in the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) in 13 healthy controls (HC) and 13 patients with mild cognitive impairment (MCI) using single-voxel magnetic resonance spectroscopy at 7T. Levels of γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartylglutamate (NAAG), N-acetylaspartate (NAA), and myo-inositol (mI) were quantified relative to total creatine (tCr). The effect of diagnosis on metabolite levels, and relationships between metabolite levels and memory and executive function, correcting for age, were investigated. MCI patients showed significantly decreased GABA/tCr (ACC, PCC), Glu/tCr (PCC), and NAA/tCr (PCC), and significantly increased mI/tCr (ACC). In the combined group, worse episodic verbal memory performance was correlated with lower Glu/tCr (PCC), lower NAA/tCr (PCC), and higher mI/tCr (ACC, PCC). Worse verbal fluency performance was correlated with lower GSH/tCr (PCC). In summary, MCI is associated with decreased GABA and Glu, most consistently in the PCC. Further studies in larger patient samples should be undertaken to determine the utility of 7T magnetic resonance spectroscopy in detecting MCI-related neurochemical changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.