Evidence map›Paper›PMID 30390444›Full record

ArticlePsychoneuroendocrinology2019

Associations of cord blood leptin and adiponectin with children's cognitive abilities.

Nan Li, Tye E Arbuckle, Gina Muckle, Bruce P Lanphear, Michel Boivin, Aimin Chen, Linda Dodds, William D Fraser, Emmanuel Ouellet, Jean R Séguin and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00129324 nacompletednot on this map

Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health

TypeinterventionalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran2003 to 2018Enrolled468ConditionsEnvironmental Exposures, Child Development, Lead and Injury ReductionArmsLead Hazard Control Intervention, Injury Hazard Control Intervention
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024
    Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 2 countries.

Nan LiDepartment of Epidemiology, Brown University, Providence, RI, United States. Electronic address: nan_li1@brown.edu.
Tye E ArbucklePopulation Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.
Gina MuckleSchool of Psychology, Laval University, Ville de Québec, Québec, Canada.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, British Columbia, Canada; Child and Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada.
Michel BoivinSchool of Psychology, Laval University, Ville de Québec, Québec, Canada.
Aimin ChenDivision of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Linda DoddsPerinatal Epidemiology Research Unit, IWK Health Center, Halifax, Canada.
William D FraserCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Mother and Child University Hospital Center, Montreal, Québec, Canada; Centre de recherche du CHUS (CHU de Sherbrooke), University of Sherbrooke, Sherbrooke, Québec, Canada.
Emmanuel OuelletCHU de Québec-Université Laval Research Center, Ville de Québec, Québec, Canada.
Jean R SéguinCentre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Mother and Child University Hospital Center, Montreal, Québec, Canada; Department of Psychiatry, University of Montréal, Montréal, Québec, Canada.
Maria P VelezDepartment of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.
Kimberly YoltonDepartment of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, United States.
Université Laval · CABrown University · USCentre Hospitalier Universitaire Sainte-Justine · CACincinnati Children's Hospital Medical Center · USHealth Canada · CAIzaak Walton Killam Health Centre · CAQueen's University · CASimon Fraser University · CAUniversité de Sherbrooke · CAUniversity of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
A Community-Based Trial to Prevent Lead Poisoning and InjuriesR01ES014575 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2007 to 2011
$2.9M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Endocrine Disrupting Chemicals, Thyroid Hormones, and Child NeurobehaviorR01ES024381 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2015 to 2018
$2.4M
Canadian Institute of Health Research MOP-81285NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES014575NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES024381NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES028277
6 · The paper itself

Abstract

Background Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children's intelligence test scores. Methods We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children's Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log

Indexed as

AdiponectinBiomarkersChild DevelopmentChild, PreschoolCognitionFemaleFetal BloodHumansIntelligenceIntelligence TestsLeptinMaleMemory, Short-TermPregnancyPrenatal Exposure Delayed EffectsAdiponectinBiomarkersLeptinAdipocytokinesChildrenCognitive abilitiesIntelligence quotient

Identifiers

PMID30390444
PMCPMC6239208
OpenAlexW2898326025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.