Evidence map›Paper›PMID 30390433›Full record

ArticleiScience2018

Balanced Activity between Kv3 and Nav Channels Determines Fast-Spiking in Mammalian Central Neurons.

Yuanzheng Gu, Dustin Servello, Zhi Han, Rupa R Lalchandani, Jun B Ding, Kun Huang, Chen Gu

Abstract read
In one paragraph

Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Proper localization of the SCA13-linked KNeurobiology of disease · 2026
    Article
  2. AProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
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  17. Biophysical KeLife · 2022
    Article
  18. Resurgent NaNature communications · 2021
    Article
  19. Article
  20. Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanzheng GuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, 182 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA.
Dustin ServelloMolecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
Zhi HanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; College of Software, Nankai University, Tianjin 300071, China; Regenstrief Institute, Indianapolis, IN 46202, USA.
Rupa R LalchandaniDepartment of Neurosurgery, and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Jun B DingDepartment of Neurosurgery, and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Kun HuangDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Regenstrief Institute, Indianapolis, IN 46202, USA; School of Biomedical Engineering, Shenzhen University, Shenzhen 518037, China.
Chen GuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, 182 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gu.49@osu.edu.

Funding

Dopamine modulation of synaptic plasticity and integration in the striatumR01NS091144 · NINDS · STANFORD UNIVERSITY · PI Jun Ding · 2015 to 2026
$4.2M
Polarized Initiation of Varicosity Formation in Central Neuron MechanosensationR01NS093073 · NINDS · OHIO STATE UNIVERSITY · PI GU, CHEN · 2016 to 2025
$3.3M
Mechanism and function of Kv channel targetingR01NS062720 · NINDS · OHIO STATE UNIVERSITY · PI GU, CHEN · 2009 to 2013
$1.4M
Regulation of gray matter myelination by adolescent binge ethanol treatmentR21AA024873 · NIAAA · OHIO STATE UNIVERSITY · PI GU, CHEN · 2017 to 2018
$406k
NIAAA NIH HHS R21 AA024873NINDS NIH HHS R01 NS062720NINDS NIH HHS R01 NS091144NINDS NIH HHS R01 NS093073
6 · The paper itself

Abstract

Fast-spiking (FS) neurons can fire action potentials (APs) up to 1,000 Hz and play key roles in vital functions such as sound location, motor coordination, and cognition. Here we report that the concerted actions of Kv3 voltage-gated K

Indexed as

BiophysicsMolecular NeuroscienceNeuroscience

Identifiers

PMID30390433
PMCPMC6218699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.