Evidence map›Paper›PMID 30390211›Full record

ArticleActa neurologica Belgica2018

The MMSE should not be the sole indicator of fitness to drive in mild Alzheimer's dementia.

D Piersma, A B M Fuermaier, D de Waard, P P De Deyn, R J Davidse, J de Groot, M J A Doumen, R A Bredewoud, R Claesen, A W Lemstra and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurologica Belgica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. [Current Evidence for Assessing Fitness to Drive of People with Cognitive Impairment: A Systematic Review].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

D PiersmaDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands. d.piersma@rug.nl.ORCID http://orcid.org/0000-0001-9617-1098
A B M FuermaierDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
D de WaardDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
P P De DeynDepartment of Neurology and Alzheimer Research Center, University Medical Center Groningen, Groningen, The Netherlands.
R J DavidseSWOV Institute for Road Safety Research, The Hague, The Netherlands.
J de GrootSWOV Institute for Road Safety Research, The Hague, The Netherlands.
M J A DoumenDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
R A BredewoudCBR Dutch Driving Test Organisation, Rijswijk, The Netherlands.
R ClaesenCBR Dutch Driving Test Organisation, Rijswijk, The Netherlands.
A W LemstraDepartment of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
A VermeerenDepartment of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands.
R PondsDepartment of Psychiatry and Neuropsychology, School of Mental Health and Neurosciences (MHeNS), Maastricht University, Maastricht, The Netherlands.
F VerheyDepartment of Psychiatry and Neuropsychology, School of Mental Health and Neurosciences (MHeNS), Maastricht University, Maastricht, The Netherlands.
W H BrouwerDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
O TuchaDepartment of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, The Netherlands.
University of Groningen · NLMaastricht University · NLEuropean Patent Organisation · NLStichting Wetenschappelijk Onderzoek Verkeersveiligheid · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversity Medical Center Groningen · NL

Funding

Ministerie van Infrastructuur en Milieu 5000001470/31052108
6 · The paper itself

Abstract

Since Alzheimer's disease may affect driving performance, patients with Alzheimer's disease are assessed on fitness to drive. On-road driving assessments are widely used, and attempts have also been made to develop strategies to assess fitness to drive in a clinical setting. Preferably, a first indication of fitness to drive is obtained quickly after diagnosis using a single test such as the Mini-Mental State Examination (MMSE). The aim of this study is to investigate whether the MMSE can be used to predict whether patients with Alzheimer's disease will pass or fail an on-road driving assessment. Patients with Alzheimer's disease (n = 81) participated in a comprehensive fitness-to-drive assessment which included the MMSE as well as an on-road driving assessment [PLoS One 11(2):e0149566, 2016]. MMSE cutoffs were applied as suggested by Versijpt and colleagues [Acta Neurol Belg 117(4):811-819, 2017]. All patients with Alzheimer's disease who scored below the lower cutoff (MMSE ≤ 19) failed the on-road driving assessment. However, a third of the patients with Alzheimer's disease who scored above the upper cutoff (MMSE ≥ 25) failed the on-road driving assessment as well. We conclude that the MMSE alone has insufficient predictive value to correctly identify fitness to drive in patients with very mild-to-mild Alzheimer's disease implicating the need for comprehensive assessments to determine fitness to drive in a clinical setting.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAutomobile DrivingFemaleHumansMaleMental Status and Dementia TestsMiddle AgedSeverity of Illness IndexAlzheimer’s dementiaDrivingFitness to driveMMSE

Identifiers

PMID30390211
PMCPMC6244746
OpenAlexW2898754581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.