ArticleActa neuropathologica2019
Inner ear pathologies impair sodium-regulated ion transport in Meniere's disease.
Article in Acta neuropathologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 82 citations in OpenAlex.
- Trial
- Characterization of the Middle Ear Microbiome in Meniere's Disease by 16S rRNA Gene Sequencing Compared to Chronic Suppurative Otitis Media.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Review
- Review
- Cochlear Neural Degeneration Is Widespread in Ménière's Disease: A Temporal Bone Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Modern Perspectives on the Mechanisms and Non-Genetic Factors in Ménière's Disease-A Narrative Review.Biomedicines · 2026Review
- Repurposing Renin-Angiotensin System Drugs for the Treatment of Audiovestibular Disorders.Journal of clinical medicine · 2026Review
- Dual-target corticosteroid therapy for refractory Ménière's disease: influence of vestibular aqueduct patency and endotypes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Vestibular Aqueduct Hypoplasia Identifies Semicircular Canal Dehiscence Patients Who Progress to Meniere's Disease.Otology & neurotology open · 2025Article
- Review
- Hyperplastic growth, not hydrostatic distension, in endolymphatic hydrops in humans challenges the classic view of Meniere's disease.Scientific reports · 2025Article
- 7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière's disease and endolymphatic hydrops: an exploratory study.BMC medical imaging · 2025Observational
- Contrast Agent Uptake in Endolymphatic Sac and Duct: Inverse Relation to Endolymphatic Hydrops.The Laryngoscope · 2025Article
- Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Surgery.Clinical and experimental otorhinolaryngology · 2025Article
- Ménière's disease and vestibular migraine: a narrative review of pathogenetic insights, diagnostic evolution, and clinical management advances.Frontiers in neurology · 2025Review
- A modern conceptual framework for study and treatment of Meniere's disease.Frontiers in neurology · 2025Review
- IL-1β promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in Ménière's disease.Cell death discovery · 2024Article
- Retrolabyrinthine Bone Thickness as a Radiologic Marker for the Hypoplastic Endotype in Menière Disease.AJNR. American journal of neuroradiology · 2024Article
- Article
- Assessing the optimal MRI descriptors to diagnose Ménière's disease and the added value of analysing the vestibular aqueduct.European radiology · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Meniere's disease (MD), a syndromal inner ear disease, is commonly associated with a pathological accumulation of endolymphatic fluid in the inner ear, termed "idiopathic" endolymphatic hydrops (iEH). Although numerous precipitating/exacerbating factors have been proposed for MD, its etiology remains elusive. Here, using immunohistochemistry and in situ protein-protein interaction detection assays, we demonstrate mineralocorticoid-controlled sodium transport mechanisms in the epithelium of the extraosseous portion of the endolymphatic sac (eES) in the murine and human inner ears. Histological analysis of the eES in an extensive series of human temporal bones consistently revealed pathological changes in the eES in cases with iEH and a clinical history of MD, but no such changes were found in cases with "secondary" EH due to other otological diseases or in healthy controls. Notably, two etiologically different pathologies-degeneration and developmental hypoplasia-that selectively affect the eES in MD were distinguished. Clinical records from MD cases with degenerative and hypoplastic eES pathology revealed distinct intergroup differences in clinical disease presentation. Overall, we have identified for the first time two inner ear pathologies that are consistently present in MD and can be directly linked to the pathogenesis of EH, and which potentially affect the phenotypical presentation of MD.
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Registered trials
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