ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2019
Overwintering adaptations and extreme freeze tolerance in a subarctic population of the wood frog, Rana sylvatica.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 57 citations in OpenAlex.
- Heat shock protein 70 in Cynops orientalis: bidirectional thermal regulation and metabolic optimization in amphibian climatic adaptation.BMC genomics · 2026Article
- Selection of geographical populations suitable for artificial breeding of the Northeast China Brown Frog (Rana dybowskii).Die Naturwissenschaften · 2025Article
- Contribution of reversible histone acetylation to freeze tolerance and recovery in wood frog kidneys.Scientific reports · 2025Article
- Proteomic-based prediction of functional bioactive peptides in proteins extracted fromFood chemistry: X · 2025Article
- The Whole Genome DNA Methylation Signatures of Hindlimb Muscles in Chinese Alligators during Hibernation and Active Periods.Animals : an open access journal from MDPI · 2024Article
- Thermal Tolerance and Preferred Temperature in the Critical Endangered Montseny Brook Newt (Animals : an open access journal from MDPI · 2024Article
- 100 years Journal of Comparative Physiology.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Combined effect of seasons and life history in an anuran strengthens the response and relationship between their physiology and gut microbiota.Scientific reports · 2024Article
- Comparative transcriptomic analysis delineates adaptation strategies of Rana kukunoris toward cold stress on the Qinghai-Tibet Plateau.BMC genomics · 2024Article
- The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms.iScience · 2024Article
- Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (<em>Rana dybowskii</em>).European journal of histochemistry : EJH · 2023Article
- Multi-omics Investigation of Freeze Tolerance in the Amur Sleeper, an Aquatic Ectothermic Vertebrate.Molecular biology and evolution · 2023Article
- Metabolomic Analysis Reveals That the Moor FrogAnimals : an open access journal from MDPI · 2022Article
- Article
- Metabolic responses of plasma to extreme environments in overwintering Tibetan frogs Nanorana parkeri: a metabolome integrated analysis.Frontiers in zoology · 2021Article
- Article
- Review
- Freeze tolerance and the underlying metabolite responses in the Xizang plateau frog, Nanorana parkeri.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Metabolic characteristics of overwintering by the high-altitude dwelling Xizang plateau frog, Nanorana parkeri.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Calcium-Binding Proteins in the Nervous System during Hibernation: Neuroprotective Strategies in Hypometabolic Conditions?International journal of molecular sciences · 2019Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The terrestrially hibernating wood frog (Rana sylvatica) is well-known for its iconic freeze tolerance, an overwintering adaptation that has received considerable investigation over the past 35 years. Virtually, all of this research has concerned frogs indigenous to the temperate regions of its broad range within North America. However, recent investigations have shown that frogs of subarctic populations are extremely cold hardy, being capable of surviving freezing for longer periods and at much lower temperatures as compared to conspecifics from temperate regions. Their exceptional freeze tolerance is partly supported by an enhanced cryoprotectant system that uses very high levels of urea and glucose to limit ice formation, regulate metabolism, and protect macromolecules and cellular structures from freezing/thawing stresses. In the weeks before they begin hibernating, northern frogs undertake radical physiological transitions, such as depletion of fat stores and catabolism of muscle protein, that prime the cryoprotectant system by accruing urea and stockpiling glycogen from which glucose is mobilized during freezing. Concentrations of cryoprotectants ultimately achieved in Alaskan frogs when freezing occurs vary among tissues but generally are higher than those of frogs inhabiting milder climates. This review summarizes the molecular, biochemical, and physiological adaptations permitting this northern phenotype to survive the long and harsh winters of the region.
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