Evidence map›Paper›PMID 30390097›Full record

ReviewCurrent genetics2019

Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability.

R A Greenstein, Bassem Al-Sady

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R A GreensteinDepartment of Microbiology and Immunology, George Williams Hooper Foundation, University of California San Francisco, San Francisco, CA, 94143, USA.
Bassem Al-SadyDepartment of Microbiology and Immunology, George Williams Hooper Foundation, University of California San Francisco, San Francisco, CA, 94143, USA. bassem.al-sady@ucsf.edu.ORCID http://orcid.org/0000-0002-8996-7941

Funding

Reconstructing dynamic epigenetic genome partitioning in single stem cellsDP2GM123484 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AL-SADY, BASSEM · 2016 to 2020
$2.5M
NIGMS NIH HHS DP2 GM123484NIH Office of the Director DP2 GM 123484
6 · The paper itself

Abstract

Heterochromatin spreading, the propagation of repressive chromatin along the chromosome, is a reaction critical to genome stability and defense, as well as maintenance of unique cell fates. Here, we discuss the intrinsic properties of the spreading reaction and circumstances under which its products, formed distal to DNA-encoded nucleation sites, can be epigenetically maintained. Finally, we speculate that the epigenetic properties of heterochromatin evolved together with the need to stabilize cellular identity.

Indexed as

Epigenesis, GeneticGene SilencingGenomic InstabilityAnimalsChromatin Assembly and DisassemblyFungiGenomicsHeterochromatinHumansInheritance PatternsHeterochromatinCellular identityChromatin structureDNA methylationEpigenetic inheritanceHeterochromatin spreadingHistone 3 lysine 9 methylationHistone turnover

Identifiers

PMID30390097
PMCPMC6452905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.