Evidence map›Paper›PMID 30390091›Full record

ArticleCell death and differentiation2019

Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons.

Qijin Zhao, Daoyuan Lu, Jing Wang, Beibei Liu, Heping Cheng, Mark P Mattson, Aiwu Cheng

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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  19. Mitochondrial RNA in Alzheimer's Disease Circulating Extracellular Vesicles.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Qijin ZhaoLaboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Daoyuan LuLaboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Jing WangLaboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Beibei LiuLaboratory of Calcium Signaling and Mitochondrial Biomedicine, Institute of Molecular Medicine, Peking University, 100871, Beijing, China.
Heping ChengLaboratory of Calcium Signaling and Mitochondrial Biomedicine, Institute of Molecular Medicine, Peking University, 100871, Beijing, China.
Mark P MattsonLaboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA. mark.mattson@nih.gov.
Aiwu ChengLaboratory of Neurosciences, Biomedical Research Center, National Institute on Aging Intramural Research Program, 251 Bayview Blvd, Baltimore, MD, 21224, USA. chengai@mail.nih.gov.
Peking University · CNInstitute on Aging · USJohns Hopkins Medicine · USNational Institute on Aging · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial superoxide dismutase 2 (SOD2) is a major antioxidant defense enzyme. Here we provide evidence that SOD2 plays critical roles in maintaining calcium homeostasis in newly generated embryonic cerebral cortical neurons, which is essential for normal mitochondrial function and subcellular distribution, and neurite outgrowth. Primary cortical neurons in cultures established from embryonic day 15 SOD2

Indexed as

AnimalsCalciumCerebral CortexDynaminsMiceMitochondriaMitochondrial DynamicsNeuronal OutgrowthNeuronsPhosphorylationSuperoxide DismutaseSuperoxide Dismutase 2CalciumDnm1l protein, mouseDynaminsSuperoxide DismutaseSuperoxide Dismutase 2

Identifiers

PMID30390091
PMCPMC6748124
OpenAlexW2899102128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.