ReviewHypertension research : official journal of the Japanese Society of Hypertension2019
Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The multifaceted impact of a high-salt environment on the immune system and its contribution to salt-sensitive hypertension.Biochemistry and biophysics reports · 2025Review
- Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading.Kidney & blood pressure research · 2025Article
- Salt, Not Always a Cardiovascular Enemy? A Mini-Review and Modern Perspective.Medicina (Kaunas, Lithuania) · 2022Review
- Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension.Clinical science (London, England : 1979) · 2022Article
- Identification of sodium homeostasis genes in Camelus bactrianus by whole transcriptome sequencing.FEBS open bio · 2022Article
- Role of the microbiota in hypertension and antihypertensive drug metabolism.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Frequency of alcohol drinking modifies the association between salt intake and albuminuria: a 1-year observational study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Observational
- Female Sex, a Major Risk Factor for Salt-Sensitive Hypertension.Current hypertension reports · 2020Review
- High-salt intake increases TRPC3 expression and enhances TRPC3-mediated calcium influx and systolic blood pressure in hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Sodium-induced inflammation-an invisible player in resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Is alcohol drinking a key factor contributing to salt sensitivity?Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Drinking frequency modifies an association between salt intake and blood pressure: A cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
High-salt intake is one of the major dietary determinants of increased blood pressure and cardiovascular disease. Thus, there is scientific and medical interest in understanding the mechanistic abnormalities mediating the pressor effects of salt (salt sensitivity). According to historical theory, salt sensitivity stems from an impairment in renal function (referred to as "abnormal pressure natriuresis" or a "natriuretic handicap"), which causes salt-sensitive subjects to excrete a sodium load more slowly, and retain more of it than salt-resistant normotensive controls. However, this historical view has come under intense scrutiny because of growing awareness that in salt-sensitive subjects, acute salt loading does not usually induce greater increases in sodium balance and cardiac output than those induced by salt loading in salt-resistant normotensive controls. Here we highlight pioneering studies from Japan that challenge the historical thinking and provide insights into a contemporary theory of salt sensitivity termed the "vasodysfunction theory." According to this theory, initiation of salt-induced hypertension usually involves abnormal vascular resistance responses to increased salt intake, not greater renal retention of a salt load in salt-sensitive subjects than in normal subjects. By shifting the focus from the historical theory to a contemporary final common pathway for the pathogenesis of salt sensitivity, research from Japan is building the scientific foundation for more effective approaches to the prevention and treatment of salt-induced hypertension. Among the most promising approaches are dietary strategies for reducing the risk for salt-induced hypertension that do not depend on reducing salt consumption in the population.
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