ArticleScientific reports2018
Dopamine release in mushroom bodies of the honey bee (Apis mellifera L.) in response to aversive stimulation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- High-throughput single-fly LC-MS/MS for quantitative profiling of biogenic amines in Drosophila.PloS one · 2026Article
- Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera).Nature communications · 2025Article
- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
- Fast-Scan Cyclic Voltammetry (FSCV) Reveals Behaviorally Evoked Dopamine Release by Sugar Feeding in the Adult Drosophila Mushroom Body.Angewandte Chemie (International ed. in English) · 2022Article
- Differential Expression of Three Dopamine Receptors in Varroa-Resistant Honey Bees.Journal of insect science (Online) · 2022Article
- Robustness of the honeybee neuro-muscular octopaminergic system in the face of cold stress.Frontiers in physiology · 2022Article
- Plasticity and modulation of olfactory circuits in insects.Cell and tissue research · 2021Review
- A neural algorithm for Drosophila linear and nonlinear decision-making.Scientific reports · 2020Article
- Opponent processes in visual memories: A model of attraction and repulsion in navigating insects' mushroom bodies.PLoS computational biology · 2020Article
- Increased aggression and reduced aversive learning in honey bees exposed to extremely low frequency electromagnetic fields.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, aversive (electric shock) stimuli have been shown to activate subpopulations of dopaminergic neurons with terminals in the mushroom bodies (MBs) of the brain. While there is compelling evidence that dopamine (DA)-induced synaptic plasticity underpins the formation of aversive memories in insects, the mechanisms involved have yet to be fully resolved. Here we take advantage of the accessibility of MBs in the brain of the honey bee to examine, using fast scan cyclic voltammetry, the kinetics of DA release and reuptake in vivo in response to electric shock, and to investigate factors that modulate the release of this amine. DA increased transiently in the MBs in response to electric shock stimuli. The magnitude of release varied depending on stimulus duration and intensity, and a strong correlation was identified between DA release and the intensity of behavioural responses to shock. With repeated stimulation, peak DA levels increased. However, the amount of DA released on the first stimulation pulse typically exceeded that evoked by subsequent pulses. No signal was detected in response to odour alone. Interestingly, however, if odour presentation was paired with electric shock, DA release was enhanced. These results set the stage for analysing the mechanisms that modulate DA release in the MBs of the bee.
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