Evidence map›Paper›PMID 30389967›Full record

ArticleScientific reports2018

Single molecule localisation microscopy reveals how HIV-1 Gag proteins sense membrane virus assembly sites in living host CD4 T cells.

Charlotte Floderer, Jean-Baptiste Masson, Elise Boilley, Sonia Georgeault, Peggy Merida, Mohamed El Beheiry, Maxime Dahan, Philippe Roingeard, Jean-Baptiste Sibarita, Cyril Favard and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Membrane bending energy selects for compact growth of protein assemblies.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Charlotte FlodererInfectious Disease Research Institute of Montpellier (IRIM), UMR9004 CNRS, University of Montpellier, 1919 route de Mende, 34293, Montpellier, France.
Jean-Baptiste MassonDecision and Bayesian Computation, UMR 3571 CNRS, Pasteur Institute, Paris, France.
Elise BoilleyInfectious Disease Research Institute of Montpellier (IRIM), UMR9004 CNRS, University of Montpellier, 1919 route de Mende, 34293, Montpellier, France.
Sonia GeorgeaultINSERM U966 and IBiSA EM Facility, University of Tours, Tours, France.
Peggy MeridaInfectious Disease Research Institute of Montpellier (IRIM), UMR9004 CNRS, University of Montpellier, 1919 route de Mende, 34293, Montpellier, France.
Mohamed El BeheiryLight and Optical Control of Cellular Organization, Curie Institute, UMR, 168 CNRS, Paris, France.
Maxime DahanLight and Optical Control of Cellular Organization, Curie Institute, UMR, 168 CNRS, Paris, France.
Philippe RoingeardINSERM U966 and IBiSA EM Facility, University of Tours, Tours, France.ORCID http://orcid.org/0000-0001-9131-3341
Jean-Baptiste SibaritaInterdisciplinary Institute for Neuroscience, UMR 5297 CNRS, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0002-9920-7700
Cyril FavardInfectious Disease Research Institute of Montpellier (IRIM), UMR9004 CNRS, University of Montpellier, 1919 route de Mende, 34293, Montpellier, France. cyril.favard@irim.cnrs.fr.ORCID http://orcid.org/0000-0002-8304-2980
Delphine MuriauxInfectious Disease Research Institute of Montpellier (IRIM), UMR9004 CNRS, University of Montpellier, 1919 route de Mende, 34293, Montpellier, France. delphine.muriaux@irim.cnrs.fr.
Centre National de la Recherche Scientifique · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring virus assembly at the nanoscale in host cells remains a major challenge. Human immunodeficiency virus type 1 (HIV-1) components are addressed to the plasma membrane where they assemble to form spherical particles of 100 nm in diameter. Interestingly, HIV-1 Gag protein expression alone is sufficient to produce virus-like particles (VLPs) that resemble the immature virus. Here, we monitored VLP formation at the plasma membrane of host CD4

Indexed as

Virus AssemblyCD4-Positive T-LymphocytesCell Membranegag Gene Products, Human Immunodeficiency VirusHIV-1HumansIntravital MicroscopyJurkat CellsMicroscopy, FluorescenceMutagenesis, Site-DirectedMutationRecombinant ProteinsRNA, ViralSingle Molecule ImagingTransfectiongag Gene Products, Human Immunodeficiency VirusRecombinant ProteinsRNA, Viral

Identifiers

PMID30389967
PMCPMC6214999
OpenAlexW2898635015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.