Evidence map›Paper›PMID 30389955›Full record

Trial reportScientific reports2018

Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults.

Jeeyeon Kim, Miesha Farahmand, Colleen Dunn, Carlos E Milla, Rina I Horii, Ewart A C Thomas, Richard B Moss, Jeffrey J Wine

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Clinical Phenotypes of Cystic Fibrosis Carriers.Annual review of medicine · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jeeyeon KimCystic Fibrosis Research Laboratory, Stanford University, Stanford, CA, 94305, USA.
Miesha FarahmandCystic Fibrosis Research Laboratory, Stanford University, Stanford, CA, 94305, USA.
Colleen DunnDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Carlos E MillaDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Rina I HoriiDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.
Ewart A C ThomasDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.
Richard B MossDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jeffrey J WineCystic Fibrosis Research Laboratory, Stanford University, Stanford, CA, 94305, USA. wine@stanford.edu.
Stanford University · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
CatheterScope for Intraluminal Image of Early.NeoplasiaR33CA094303 · NCI · UNIVERSITY OF WASHINGTON · PI SEIBEL, ERIC J · 2004 to 2006
$1.7M
CatheterScope for Intraluminal Image of Early.NeoplasiaR21CA094303 · NCI · UNIVERSITY OF WASHINGTON · PI SEIBEL, ERIC J · 2003 to 2003
$151k
NCI NIH HHS R21 CA094303NCI NIH HHS R33 CA094303NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

To determine if ivacaftor (Kalydeco) influences non-CF human CFTR function in vivo, we measured CFTR-dependent (C-sweat) and CFTR-independent (M-sweat) rates from multiple identified sweat glands in 8 non-CF adults. The two types of sweating were stimulated sequentially with intradermal injections of appropriate reagents; each gland served as its own control via alternating off-on drug tests on both arms, given at weekly intervals with 3 off and 3 on tests per subject. We compared drug effects on C-sweating stimulated by either high or low concentrations of β-adrenergic cocktail, and on methacholine-stimulated M-sweating. For each subject we measured ~700 sweat volumes from ~75 glands per arm (maximum 12 readings per gland), and sweat volumes were log-transformed for statistical analysis. T-tests derived from linear mixed models (LMMs) were more conservative than the familiar paired sample t-tests, and show that ivacaftor significantly increased C-sweating stimulated by both levels of agonist, with a larger effect in the low cocktail condition; ivacaftor did not increase M-sweat. Concurrent sweat chloride tests detected no effect of ivacaftor. We conclude that ivacaftor in vivo increases the open channel probability (P

Indexed as

AdultAminophenolsChloride Channel AgonistsChloridesCystic Fibrosis Transmembrane Conductance RegulatorDose-Response Relationship, DrugFemaleHumansMaleQuinolonesSweatSweat GlandsSweatingAminophenolsCFTR protein, humanChloride Channel AgonistsChloridesCystic Fibrosis Transmembrane Conductance RegulatorivacaftorQuinolones

Identifiers

PMID30389955
PMCPMC6214959
OpenAlexW2898659251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.