ArticleNature communications2018
Programming molecular topologies from single-stranded nucleic acids.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Aptamer-based nanoparticle drug delivery system designed for targeting GPC3-positive liver cancer.Journal of pharmaceutical analysis · 2026Article
- Machine learning-optimized long single-stranded DNA synthesis technology empowers high-precision diagnostic-therapeutic integration in living cells.Nucleic acids research · 2026Article
- Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 31 and 52 knots.Nucleic acids research · 2026Article
- Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei.Nature communications · 2025Article
- Controlled Reassociation of Multistranded, Polycrossover DNA Molecules into Double Helices.Nano letters · 2025Article
- Folding Competition and Dynamic Transformation in DNA Origami: Parallel Versus Antiparallel Crossovers.Small methods · 2025Article
- Encoding signal propagation on topology-programmed DNA origami.Nature chemistry · 2024Article
- Self-assembly of DNA parallel double-crossover motifs.Nanoscale · 2024Article
- Recent Advances in DNA Origami-Engineered Nanomaterials and Applications.Chemical reviews · 2023Review
- A single strand: A simplified approach to DNA origami.Frontiers in chemistry · 2023Review
- Selective and Reversible Ligand Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy.Chembiochem : a European journal of chemical biology · 2022Article
- Assembly of RNA Nanostructures from Double-Crossover Tiles.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Imaging in vivo acetylcholine release in the peripheral nervous system with a fluorescent nanosensor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chiral Systems Made from DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Meta-DNA structures.Nature chemistry · 2020Article
- Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation.Nucleic acids research · 2020Article
- Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids.Nature communications · 2020Article
- Bioproduction of pure, kilobase-scale single-stranded DNA.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remains challenging. Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by hierarchical folding in a prescribed order. Sets of DNA and RNA knots of two- or three-dimensional shapes have been designed and constructed (ranging from 1700 to 7500 nucleotides), and they exhibit complex topological features, with high crossing numbers (from 9 up to 57). These single-stranded DNA/RNA knots can be replicated and amplified enzymatically in vitro and in vivo. This work establishes a general platform for constructing nucleic acid nanostructures with complex molecular topologies.
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